杰克跳蚁毒液过敏患者的健康相关生活质量:毒液过敏生活质量问卷 "VQLQ的验证。

IF 8.2 1区 医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI:10.1016/j.jaip.2024.11.009
Kymble Spriggs, Marsus Pumar, Elizabeth Leahy, Nicole Weibel, Sara Barnes
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引用次数: 0

摘要

背景:评估对杰克跳蚁(JJA)毒液过敏的患者的健康相关生活质量(HRQoL),杰克跳蚁是一种膜翅目昆虫,原产于澳大利亚东南部地区。尽管据估计,在某些地区,全身性过敏症状的人群发病率高达 3%,但此前尚未对此进行过研究:目的:验证 VQLQ HRQoL 工具(之前曾在黄蜂和蜜蜂毒液过敏患者中进行过验证)在这一特定蚁毒过敏人群中的应用:方法:对在国立毒液免疫治疗中心就诊的歼击机毒液临床过敏患者使用 14 个项目的 VQLQ 调查工具。在毒液免疫疗法治疗过程中的不同时间点进行调查。结果:271人提供了调查数据,其中中位年龄为52岁(3-85岁),呈双峰分布,25%的人年龄小于18岁。内部一致性非常好,Cronbach 值为 0.95。VQLQ 与 EO 的正相关性为 0.44(p < 0.001),证明了横断面有效性。在对成人和儿童进行分层时,其表现几乎相同:VQLQ 似乎能为鸦片琼毒液过敏患者的 HRQoL 测量提供相似的性能,这一点之前已在其他膜翅目物种中得到证实。此外,这是第一项专门针对 3-18 岁儿童群体的横断面有效性研究。
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Health-Related Quality of Life in Jack Jumper Ant Venom Allergy: Validation of the Venom-Allergy Quality of Life Questionnaire.

Background: We assessed health-related quality of life (HRQoL) in patients with allergy to the venom of the jack jumper ant (JJA), Myrmecia pilosula, a Hymenoptera order species native and endemic to the Southeastern quarter of Australia. To our knowledge, this has not previously been studied despite an estimated population prevalence of generalized allergic symptoms as high as 3% in some areas.

Objective: To validate the Venom Quality of Life Questionnaire (VQLQ) HRQoL instrument, which was previously validated in patients with wasp and bee venom allergy, for use in this specific ant venom-allergic population.

Methods: The 14-item VQLQ survey instrument was administered to patients with clinical allergy to JJA venom presenting at the state treatment center for venom immunotherapy. Surveys were performed at different time points of the progression through visits for venom immunotherapy treatment. We performed cross-sectional and longitudinal validation against the Expectation of Outcome (EO) questionnaire by determining correlations and agreement.

Results: A total of 271 individuals contributed survey data, median age 52 years (range, 3-85 years; bimodal distribution with 25% aged <18 years). Internal consistency was excellent (Cronbach α = 0.95). Cross-sectional validity was demonstrated with a positive correlation of VQLQ to EO of 0.44 (P < .001). Performance was nearly identical when stratified into adults and children (aged <18 years). Longitudinal validity was suggested as both VQLQ and EO improved over time in both adults and children, but this had paired correlation at only two time points in adults. Bland-Altman analysis demonstrated acceptable agreement between VQLQ and EO and no evidence of systematic bias.

Conclusions: The VQLQ appears to offer performance of HRQoL measurement in patients with JJA venom allergy, similar to that previously demonstrated in other Hymenoptera species. In addition, this study demonstrates cross-sectional validity specifically in a pediatric population aged 3 to 18 years.

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来源期刊
CiteScore
11.10
自引率
9.60%
发文量
683
审稿时长
50 days
期刊介绍: JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.
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