副病毒 B19 产生的膜损伤会将红细胞标记为衰老红细胞,是病毒引发的贫血症的加重原因之一

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical hypotheses Pub Date : 2024-11-19 DOI:10.1016/j.mehy.2024.111524
Josefina Valadez-García , Iris Ashanty Soto-Valerio , Maximiliano Cueva-Berea , Guadalupe Trinidad Zavala-Padilla , Ismael Bustos-Jaimes
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引用次数: 0

摘要

Parvovirus B19(B19V)是红斑性传染性皮肤病和其他疾病的病原体,包括患有镰状细胞病、球形红细胞增多症或地中海贫血症等潜在溶血性疾病的患者的再生障碍性贫血。已经证实,B19V 通过感染骨髓中的红细胞祖细胞(EPC)影响红细胞(RBC)的发育。B19V 感染的第一步是病毒与 EPC 表面的糖磷脂(GSL)球苷(Gb4)结合,暂时停止红细胞生成。虽然健康患者对这种感染的耐受性良好,但它会导致贫血患者出现严重的再生障碍性危机。Gb4 也是红细胞膜上最丰富的中性糖脂。有文献记载,B19V 及其病毒样颗粒(VLP)会对红细胞产生血凝作用。我们推测,B19V 与红细胞膜结合后一定会引起变化,从而损害其功能并缩短细胞的半衰期,这也是 B19V 导致贫血的一个重要原因。在此,我们提出了光学和电子显微镜证据,证明 B19V VLP 的存在会导致 RBC 表面发生形态变化,从而支持了这一假设。
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Membrane damage produced by parvovirus B19 tags erythrocytes as senescent and is an aggravating cause of virus-triggered anemias
Parvovirus B19 (B19V) is the causative agent of erythema infectiosum and other diseases, including aplastic anemia in individuals with underlying hemolytic disorders such as sickle cell disease, spherocytosis or thalassemia. It has been well-established that B19V affects the development of red blood cells (RBC) by infecting erythroid progenitor cells (EPC) in the bone marrow. The first step in B19V infection is the binding of the virion to the glycosphingolipid (GSL) globoside (Gb4) on the EPC surface and temporarily stopping erythropoiesis. Although this infection is tolerated well by healthy patients, it can lead to severe aplastic crises in anemia patients. Gb4 is also the most abundant neutral glycolipid in the erythrocyte membrane. It has been documented that B19V and its virus-like particles (VLP) produce hemagglutination of RBCs. We hypothesized that B19V binding to the RBC membrane must induce changes impairing its function and reducing the cell’s half-life, being an aggravating cause of anemias produced by B19V. Here, we present optic and electronic microscopy evidence of morphological changes on the surface of the RBC produced by the presence of B19V VLP, supporting this hypothesis.
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来源期刊
Medical hypotheses
Medical hypotheses 医学-医学:研究与实验
CiteScore
10.60
自引率
2.10%
发文量
167
审稿时长
60 days
期刊介绍: Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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