败血症中的肾素-血管紧张素-醛固酮系统及其与外源性血管紧张素 II 的临床调节作用

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE Critical Care Pub Date : 2024-11-26 DOI:10.1186/s13054-024-05123-7

Matthieu Legrand, Ashish K. Khanna, Marlies Ostermann, Yuki Kotani, Ricard Ferrer, Massimo Girardis, Marc Leone, Gennaro DePascale, Peter Pickkers, Pierre Tissieres, Filippo Annoni, Katarzyna Kotfis, Giovanni Landoni, Alexander Zarbock, Patrick M. Wieruszewski, Daniel De Backer, Jean-Louis Vincent, Rinaldo Bellomo

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引用次数: 0

摘要

脓毒症中肾素-血管紧张素-醛固酮系统（RAAS）的失调是一种复杂而早期的现象，可能对器官衰竭和患者预后有重要影响。随着对脓毒性休克中 RAAS 的病理生理学和复杂性有了更深入的了解，外源性血管紧张素 II 被用作一种新的治疗药物。在这篇综述中，我们报告了多国、多学科专家小组就 RAAS 调节在脓毒症中的作用和意义以及外源性血管紧张素 II 的使用所进行的讨论。专家小组就患者的选择和外源性血管紧张素 II 的治疗方案提出了指导性意见，这将引发进一步的研究。

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The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.

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来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.