室温自然光促进了咪唑/三唑与环丙烯酮的 DMSO/O2 催化 N-酰化反应。

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED Molecular Diversity Pub Date : 2024-11-25 DOI:10.1007/s11030-024-11039-9

Guo-Dong Shen, Zhi-Rong Zhao, Kun Bi, Yi Man, Jun-Tong Liu, Xian-Qiang Huang, Xin Lv

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引用次数: 0

摘要

在室温、无金属条件下，开发了一种前所未有的自然光促进 DMSO/O2 催化咪唑/三唑与环丙烯酮的 N-酰化反应。该策略的显著优点包括原子经济性和环境友好条件（如自然光促进、DMSO/O2 催化、室温和 DMC 作为溶剂）、立体特异性 (E)- 烯烃合成（N-酰基咪唑和三唑）、宽官能团耐受性和高反应产率。此外，典型产物（1c 和 1e）具有良好的光电流和电化学特性，有望应用于生物传感器材料领域。

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Room temperature natural light promoted DMSO/O₂-catalyzed N-acylation reaction of imidazoles/triazoles with cyclopropenones.

An unprecedented natural light promoted DMSO/O₂-catalyzed N-acylation reaction of imidazoles/triazoles with cyclopropenones at room temperature under metal-free conditions has been developed. The remarkable advantages of this strategy include atomic economy and environmentally benign conditions (such as natural light promotion, DMSO/O₂-catalysis, room temperature, and DMC as solvent), stereospecific (E)-olefins synthesis (N-acyl imidazoles and triazoles), wide functional group tolerance and high reaction yields. Furthermore, the typical products (1c and 1e) display good photocurrent and electrochemical property and are potentially applicable in biosensor materials fields.

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;