黄芩中的黄酮类化合物对口腔健康的促进作用

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED Journal of Asian Natural Products Research Pub Date : 2024-11-26 DOI:10.1080/10286020.2024.2428797

Bai-Xiang Cai, Qing-Yang Wu, Jin-Lian Huang, Jing Wu, Yang Yu, Lei Xiao, Xiang-Hai Cai

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引用次数: 0

摘要

从黄芩中寻找改善口腔炎症和消除口臭的材料，发现了一种新化合物，5,7,2',5'-四羟基-6'-甲氧基黄酮（1）和 32 种已知化合物。其中，3 种黄酮（11、17、18）、2 种二氢黄酮（23、25）、2 种黄酮苷（30、32）和 1 种查尔酮（26）可抑制口腔厌氧菌核酸杆菌、变异链球菌和牙龈卟啉单胞菌。化合物 3、14 和 18 可抑制口腔细菌金黄色葡萄球菌。化合物 5、8、13 和 21 具有很强的抑制 NO 生成的作用。此外，14 和 26 具有良好的 COX-1/2 抑制作用。这些结果表明黄芩具有潜在的口腔保健作用。

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Oral health promotion of flavonoids from Scutellaria baicalensis.

Looking for materials from Scutellaria baicalensis to improve oral inflammation and eliminate bad breath led to one new compound, 5,7,2',5'-tetrahydroxy-6'-methoxyflavone (1) and 32 known ones. Among of them, 3 flavones (11, 17, 18), 2 dihydroflavones (23, 25), 2 flavone glucosides (30, 32), and a chalcone (26) could inhibit oral anaerobic bacteria Fusobacterium nucleatum, Streptococcus mutans, and Porphyromonas gingivalis. Compounds 3, 14, 18 could inhibit oral bacterial Staphylococcus aureus. Compounds 5, 8, 13 and 21 exhibited strong inhibitory NO production. Additionally, 14 and 26 showed good COX-1/2 inhibitory effects. These results indicated S. baicalensis has potential oral health benefits.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.