Pressure Enabled Drug Delivery (PEDD) Significantly Increases Intraarterial Delivery of Embolic Microspheres to Liver Tumors in a Porcine Model.

This study aims to test the hypothesis that Pressure Enabled Drug Delivery (PEDD) with a TriNav device would increase delivery of Embospheres via hepatic artery infusion to liver tumors in an oncopig model when compared to a conventional endhole microcatheter. Embospheres (100-300um in size) were fluorescently labeled and infused into porcine liver tumors using conventional technique (n=8) or by PEDD (n=8). Liver tissue was harvested and we analyzed images with a custom Visiopharm Deep Learning algorithm (Visiopharm A/S) to quantitate signal intensity. PEDD increased Embosphere penetration into the tumor by 227% (p = 0.029) when compared to conventional methodology and improved T/N ratio from 2.7 to 4.2. These data demonstrate improved delivery into tumor tissue using PEDD, along with improved selectivity by minimizing relative off-target deposition.