{"title":"tRNA 甲基化驱动出生后早期心肌细胞成熟","authors":"Pilar Ruiz-Lozano, Mark Mercola","doi":"10.1038/s44161-024-00572-3","DOIUrl":null,"url":null,"abstract":"The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 12","pages":"1375-1376"},"PeriodicalIF":9.4000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"tRNA methylation drives early postnatal cardiomyocyte maturation\",\"authors\":\"Pilar Ruiz-Lozano, Mark Mercola\",\"doi\":\"10.1038/s44161-024-00572-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 12\",\"pages\":\"1375-1376\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00572-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00572-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
tRNA methylation drives early postnatal cardiomyocyte maturation
The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.
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