有神经精神症状的男性和女性阿尔茨海默病患者的风险因素

IF 2.5 3区医学 Q3 GERIATRICS & GERONTOLOGY Geriatric Nursing Pub Date : 2024-11-27 DOI:10.1016/j.gerinurse.2024.11.001

Philip Broughton , Addison Niles , Adebobola Imeh-Nathaniel , Samuel Imeh-Nathaniel , Richard L. Goodwin , Laurie Theriot Roley , Thomas I. Nathaniel

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引用次数: 0

摘要

背景本研究调查了阿尔茨海默病（AD）非髓性痴呆患者（ADNPS）群体中的风险因素。方法利用地区性AD护理中心的数据，研究了与男性和女性ADNPS相关的基线风险因素。结果在调整后的分析中，血脂异常（OR = 0.630，95 % CI，0.431-0.992，P = 0.017）、甲状腺功能障碍（OR = 0.549，95 % CI，0.377-0.798，P = 0.002）和脑梗塞（OR = 0.684，95 % CI，0.472-0.991，P = 0.0085）与男性 ADNPS 患者相关，而慢性心力衰竭（OR = 1.408，95 % CI，0.953-2.079，P = 0.0085）与女性 ADNPS 患者相关。

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Risk factors of male and female Alzheimer's disease patients with neuropsychiatric symptoms

Background

This study investigates risk factors in the population of Alzheimer disease (AD) patients with NPS (ADNPS).

Method

Baseline risk factors associated with male and female ADNPS were examined using data from a regional AD care center. Univariate analysis was used to determine factors in male and female patients, while logistic regression models were developed to generate odds ratios (OR) to predict risk factors that are associated with male or female ADNPS.

Results

In the adjusted analysis, dyslipidemia (OR = 0.630, 95 % CI, 0.431–0.992, P = 0.017), thyroid dysfunction (OR = 0.549, 95 % CI, 0.377–0.798, P = 0.002), and cerebral infarction (OR = 0.684, 95 % CI, 0.472–0.991, P = 0.0085) were associated with male ADNPS patients, whereas chronic heart failure (OR = 1.408, 95 % CI, 0.953–2.079, P = 0.0085) was associated with female ADNPS patients.

Conclusions

Our results reveal that female ADNPS patients were associated with heart failure, whereas male patients were associated with dyslipidemia and cerebral infarction.

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来源期刊

Geriatric Nursing 医学-护理

CiteScore

3.80

自引率

7.40%

发文量

257

审稿时长

>12 weeks

期刊介绍： Geriatric Nursing is a comprehensive source for clinical information and management advice relating to the care of older adults. The journal''s peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on care of older adults across the long term continuum. Geriatric Nursing addresses current issues related to drugs, advance directives, staff development and management, legal issues, client and caregiver education, infection control, and other topics. The journal is written specifically for nurses and nurse practitioners who work with older adults in any care setting.