综述浆果的保护作用和分子机制,应对无声的公共健康问题:非酒精性脂肪肝。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-11-14 DOI:10.3390/antiox13111389
Anshul Sharma, Hae-Jeung Lee
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)对人类健康构成无声的威胁,发病率以惊人的速度上升。非酒精性脂肪肝的治疗和预防有赖于新方法,因为目前还没有有效的治疗方案。浆果是酚类化合物的独特来源,在预防疾病和促进健康方面的作用已得到证实。然而,关于不同浆果对非酒精性脂肪肝和相关病症的影响,目前还缺乏全面的综述。因此,本综述旨在总结 21 种不同浆果中的浆果提取物、植物部分和生物活性化合物对非酒精性脂肪肝的影响。其中涉及的分子机制包括调节脂质稳态、调节氧化应激和炎症标志物,以及在不同的体外和体内非酒精性脂肪肝模型中激活不同的信号通路。此外,它们对肠道微生物群的调节作用也得到了强调。关于浆果对非酒精性脂肪肝的益处的临床干预研究还很有限;不过,本文讨论的临床研究证明了不同浆果对非酒精性脂肪肝患者的影响。未来的研究应侧重于长期临床研究,以比较不同浆果对非酒精性脂肪肝的治疗潜力。
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A Review on the Protecting Effects and Molecular Mechanisms of Berries Against a Silent Public Health Concern: Non-Alcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease (NAFLD) poses a silent threat to human health, with prevalence rising at an alarming rate. The treatment and prevention of NAFLD depend on novel approaches as no effective treatment options are currently available. Berries are unique sources of phenolic compounds that have proven roles in disease prevention and health promotion. However, a comprehensive review of the effects of different berries on NAFLD and related pathologies is lacking. Thus, the present review aims to summarize the effects of berry extracts, plant parts, and bioactive compounds from twenty-one different berries on NAFLD. The molecular mechanisms involved include the regulation of lipid homeostasis, modulation of oxidative stress and inflammation markers, and activation of different signaling pathways in different in vitro and in vivo NAFLD models. Furthermore, their modulatory effects on the gut microbiota have also been highlighted. Clinical intervention research on the benefits of berries in NAFLD is limited; nonetheless, this paper discusses clinical studies demonstrating the effects of different berries in people with NAFLD. Future research should focus on long-term clinical studies to compare the therapeutic potentials of different berries against NAFLD.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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