Rodlet Cell Morpho-Numerical Alterations as Key Biomarkers of Fish Responses to Toxicants and Environmental Stressors.

Rodlet cells (RCs) are specialised immune cells found in teleost fish, recognised for their unique morphology and potential roles in both immune responses and environmental adaptation. Herein, current knowledge on RCs is reviewed, focussing on their responsiveness to toxicants and environmental stressors. The historical context of RC research is discussed, including key milestones in the identification and characterisation of these cells. Recent studies highlight RCs' quantitative and qualitative changes in response to various pollutants, such as heavy metals, organic chemicals, and microplastics, underscoring their utility as biomarkers for environmental monitoring and assessment of ecological health. The underlying mechanisms that govern RC responses are explored, noting the limited research available at the molecular level, which hampers a comprehensive understanding of their functionality. Despite this, the consistent patterns of RC responses position them as valuable indicators of environmental health within the One Health framework, linking aquatic ecosystem integrity to broader human and animal health concerns. Additionally, the potential equivalence of RCs in other vertebrates is examined, which may provide insights into their evolutionary significance and functional roles across different species. The urgent need for further research is emphasised to enhance the understanding of RC biology and its applications in toxicology and environmental pathology.