花椒属植物抗炎镇痛作用机制综述

Acharya Balkrishna , Meenakshi Panwar , Sakshi Mishra , Vidushi Kala , Vedpriya Arya , Anurag Dabas
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引用次数: 0

摘要

在中医中,花椒属植物因其镇痛、抗炎、镇痛、消炎等作用而受到重视。该研究旨在深入了解花椒属植物如何通过靶向分子途径和调节免疫反应来减轻炎症和疼痛。方法在PubMed、ScienceDirect和b谷歌Scholar上使用目标关键词进行结构化文献检索,得到广泛的来源选择,根据严格的标准,从1978年到2023年,将其细化为104篇文章和50本书。数据提取主要集中在鉴定花椒属植物的生物活性化合物和合成治疗机制,特别是所涉及的关键途径。结果在33种传统使用的药物中,只有13种具有镇痛效果,只有两种用于治疗炎症性疾病。相比之下,发现18种同时具有抗炎和镇痛特性。此外,在各种体外/体内研究中,16种植物表现出抗炎和镇痛的潜力。只有10种具有抗炎反应,2种具有镇痛活性,4种同时具有抗炎和镇痛反应。生物活性化合物如zanthoxylumamide、zanthoaustrones C、tetrahydrobungeanol、decarene和zanthoxylumamide B通过MyD88、IRF3、MAPK和NF-κB通路表现出抗炎作用。此外,生物碱苯并苯胺和各种植物部位的精油通过减少扭动和退缩反应提供镇痛作用。现代研究支持花椒属植物治疗炎症和疼痛的传统用途,强调了通过关键途径的抗炎和镇痛作用,并建议进一步的临床安全性和有效性验证。
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A mechanistic review on Zanthoxylum species for anti-inflammatory and analgesic potentials

Introduction

In Traditional Chinese Medicine (TCM), Zanthoxylum species are valued for their analgesic and anti-inflammatory effects, relieving pain and controlling inflammation. The study aimed to provide insight into how Zanthoxylum species reduce inflammation and pain by targeting molecular pathways and regulating immune responses.

Methods

A structured literature search on PubMed, ScienceDirect, and Google Scholar using targeted keywords yielded a broad selection of sources, which were refined to include 104 articles and 50 books from 1978 to 2023 based on strict criteria. Data extraction focused on identifying bioactive compounds and synthesizing insights into the therapeutic mechanisms of Zanthoxylum species, particularly the key pathways involved.

Results

Only 13 of the 33 traditionally used species were shown to be effective in analgesic responses, and only two were employed in treating inflammation ailments. In comparison, 18 species were found to have both anti-inflammatory and analgesic properties. Furthermore, 16 species exhibited anti-inflammatory and analgesic potential in various in-vitro/in-vivo studies. Only ten species studied had anti-inflammatory responses, two had analgesic activity, and four had both anti-inflammatory and analgesic responses. Bioactive compounds like zanthoxylumamides, zanthoaustrones C, tetrahydrobungeanol, decarene, and zanthoxylumamide B exhibit anti-inflammatory effects through MyD88, IRF3, MAPK, and NF-κB pathways. Additionally, the alkaloid benzophenanthridine and essential oils from various plant parts provide analgesic effects by reducing writhing and flinching responses.

Discussion

Modern studies support the traditional use of Zanthoxylum species for inflammation and pain, highlighting anti-inflammatory and analgesic effects via key pathways and suggesting further clinical validation for safety and efficacy.
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