{"title":"包含单细胞转录组和TCR信息的人CD8+ T细胞图谱。","authors":"","doi":"10.1038/s41592-024-02529-7","DOIUrl":null,"url":null,"abstract":"We developed scAtlasVAE, a deep-learning-based method to integrate large-scale single-cell RNA sequencing data. Using this tool, we established a comprehensive, million-scale, pan-disease human CD8+ T cell reference atlas, which incorporates information on transcriptomes and the diversity of the αβ T cell receptor repertoire.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 2","pages":"239-240"},"PeriodicalIF":32.1000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human CD8+ T cell map with single-cell transcriptome and TCR information\",\"authors\":\"\",\"doi\":\"10.1038/s41592-024-02529-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We developed scAtlasVAE, a deep-learning-based method to integrate large-scale single-cell RNA sequencing data. Using this tool, we established a comprehensive, million-scale, pan-disease human CD8+ T cell reference atlas, which incorporates information on transcriptomes and the diversity of the αβ T cell receptor repertoire.\",\"PeriodicalId\":18981,\"journal\":{\"name\":\"Nature Methods\",\"volume\":\"22 2\",\"pages\":\"239-240\"},\"PeriodicalIF\":32.1000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Methods\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41592-024-02529-7\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-024-02529-7","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Human CD8+ T cell map with single-cell transcriptome and TCR information
We developed scAtlasVAE, a deep-learning-based method to integrate large-scale single-cell RNA sequencing data. Using this tool, we established a comprehensive, million-scale, pan-disease human CD8+ T cell reference atlas, which incorporates information on transcriptomes and the diversity of the αβ T cell receptor repertoire.
期刊介绍：
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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