The blue palette of life: A comprehensive review of natural bluish colorants with potential commercial applications.

Considering the growing interest for safer, environmentally friendly and healthier products, the search for natural colorants to replace their synthetic has been raised. This is particularly challenging for the rare and usually unstable bluish coloring substances. This comprehensive review describes several bluish pigments which can be obtained from natural sources (plants and mostly microorganisms), covering less known molecules to well established compounds (although no focus is given for anthocyanins). Key information about each compound, including sources, extraction procedures, properties, and potential applications, are presented. Despite many studies on these molecules, toxicological and stability studies are still lacking for many of them. Therefore, this text also discusses the regulatory requirements for approving new coloring substances. Given the increasing robustness of scientific data supporting the biological activities attributed to many of these pigments, it is possible to envisage that some of them may be commercially available for industrial applications in different fields, not only in traditional food or cosmetic uses but in pharmaceutical formulations as well.