Vikas D. Kadu, Sankala Naga Chandrudu, Mahesh G. Hublikar, Shahaji I. Bansode, Raghunath B. Bhosale
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Metal-Free Sustainable N-α-C(sp3)-H Functionalization of Arylmethylamines with Arylmethylketones to Synthesis of Kröhnke Pyridines Under Solvent-free Condition
An efficient “one pot” direct N-α-C(sp3)-H functionalization of arylmethylamines towards synthesis of substituted 2,4,6-triarylpyridines has developed. Fascinatingly, this method features O2 as an oxidant, metal-free simple reaction operation and the dual role of arylmethylamines. The self-oxidative coupling of readily available simple methylamines followed by their sequential deamination/cyclization cascade with arylmethylketones has accomplished anticipated 2,4,6-triarylpyridines (20 examples) up to 95% yield with good functional groups tolerance. The straightforward reaction condition in the presence of an oxidant O2 and generated H2O as a sole byproduct made this process environmentally friendly.
期刊介绍：
Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.
The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.
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