手术切除后辅助放疗改善肾上腺皮质癌的局部控制。

IF 1.4 4区 医学 Q4 ONCOLOGY Asia-Pacific journal of clinical oncology Pub Date : 2024-12-01 DOI:10.1111/ajco.14137
Jiawei Zhu, Ruiyi Yan, Jing Shen, Zheng Miao, Jie Shen, Ke Hu, Fuquan Zhang
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引用次数: 0

摘要

目的:肾上腺皮质癌是一种罕见的肿瘤,复发率高。本研究旨在评估术后辅助放疗对肾上腺皮质癌患者预后的影响。方法:对行根治性肿瘤切除术的肾上腺皮质癌患者进行调查。使用欧洲肾上腺肿瘤分期系统研究网络对肿瘤分期进行分类。131例患者中,15例接受了辅助放疗。接受手术和辅助放疗的患者与仅接受手术的患者进行比较。结果:辅助放疗组(n = 15)与对照组(n = 30)基线特征相似。辅助放疗组局部复发3例(20%),对照组局部复发18例(60%)(p < 0.05)。辅助放疗组3年局部无区生存率(77%)明显高于对照组(38.1%,p < 0.05)。然而,两组患者的无复发生存率和总生存率没有显著差异。结论:术后辅助放疗可明显增强肾上腺皮质癌的局部控制。它应被视为治疗的关键组成部分,特别是对于复发风险高的患者。
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Adjuvant Radiotherapy After Surgical Resection Improves Local Control in Adrenocortical Carcinoma.

Aims: Adrenocortical carcinoma is a rare cancer known for its high recurrence rate. This study aimed to evaluate the effects of postoperative adjuvant radiotherapy on the outcomes of patients with adrenocortical carcinoma.

Methods: We examined patients with adrenocortical carcinoma who had undergone curative tumor resection. Tumor stages were classified using the European Network for the Study of Adrenal Tumors staging system. Out of 131 patients, 15 underwent adjuvant radiotherapy. Patients who underwent surgery and adjuvant radiotherapy were compared with those who underwent surgery only.

Results: Baseline characteristics were similar between the adjuvant radiotherapy (n = 15) and control groups (n = 30). Local recurrence occurred in three patients (20%) who received adjuvant radiotherapy and 18 patients (60%) in the control group (p < 0.05). The estimated 3-year locoregional-free survival was significantly higher in the adjuvant radiotherapy group (77%) compared to the control group (38.1%, p < 0.05). However, there were no significant differences in recurrence-free or overall survival between the two groups.

Conclusions: Postoperative adjuvant radiotherapy significantly enhances local control of adrenocortical carcinoma. It should be considered a crucial component of treatment, particularly for patients at high risk of recurrence.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
175
审稿时长
6-12 weeks
期刊介绍: Asia–Pacific Journal of Clinical Oncology is a multidisciplinary journal of oncology that aims to be a forum for facilitating collaboration and exchanging information on what is happening in different countries of the Asia–Pacific region in relation to cancer treatment and care. The Journal is ideally positioned to receive publications that deal with diversity in cancer behavior, management and outcome related to ethnic, cultural, economic and other differences between populations. In addition to original articles, the Journal publishes reviews, editorials, letters to the Editor and short communications. Case reports are generally not considered for publication, only exceptional papers in which Editors find extraordinary oncological value may be considered for review. The Journal encourages clinical studies, particularly prospectively designed clinical trials.
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