{"title":"叶状天疱疮与大疱性类天疱疮共存1例。","authors":"Jinxiang Yuan, Xinyi Yao, Lvye Liu, Junling Zhang","doi":"10.2147/CCID.S486976","DOIUrl":null,"url":null,"abstract":"<p><p>Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are distinct autoimmune bullous skin diseases mediated by autoantibodies targeting adhesion molecules in desmosomes and hemidesmosomes structural proteins in the epidermal-basement membrane zone, respectively. The coexistence of PF and BP is rare. We present the case of a 72-year-old male with clinical and histological features of both PF and BP. Treatment with immunoglobulin (10 g/day for 3 days), intravenous dexamethasone sodium phosphate (5 mg/day for 10 days), oral triamcinolone (30 mg/day for 10 days), and minocycline hydrochloride (20 mg/day for 10 days) resulted in significant improvement. This rare case highlights the importance of accurate diagnosis and effective treatment strategies for the coexistence of PF and BP.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2725-2731"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611744/pdf/","citationCount":"0","resultStr":"{\"title\":\"Coexistence of Pemphigus Foliaceus and Bullous Pemphigoid: A Case Report.\",\"authors\":\"Jinxiang Yuan, Xinyi Yao, Lvye Liu, Junling Zhang\",\"doi\":\"10.2147/CCID.S486976\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are distinct autoimmune bullous skin diseases mediated by autoantibodies targeting adhesion molecules in desmosomes and hemidesmosomes structural proteins in the epidermal-basement membrane zone, respectively. The coexistence of PF and BP is rare. We present the case of a 72-year-old male with clinical and histological features of both PF and BP. Treatment with immunoglobulin (10 g/day for 3 days), intravenous dexamethasone sodium phosphate (5 mg/day for 10 days), oral triamcinolone (30 mg/day for 10 days), and minocycline hydrochloride (20 mg/day for 10 days) resulted in significant improvement. This rare case highlights the importance of accurate diagnosis and effective treatment strategies for the coexistence of PF and BP.</p>\",\"PeriodicalId\":10447,\"journal\":{\"name\":\"Clinical, Cosmetic and Investigational Dermatology\",\"volume\":\"17 \",\"pages\":\"2725-2731\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611744/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical, Cosmetic and Investigational Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CCID.S486976\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S486976","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Coexistence of Pemphigus Foliaceus and Bullous Pemphigoid: A Case Report.
Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are distinct autoimmune bullous skin diseases mediated by autoantibodies targeting adhesion molecules in desmosomes and hemidesmosomes structural proteins in the epidermal-basement membrane zone, respectively. The coexistence of PF and BP is rare. We present the case of a 72-year-old male with clinical and histological features of both PF and BP. Treatment with immunoglobulin (10 g/day for 3 days), intravenous dexamethasone sodium phosphate (5 mg/day for 10 days), oral triamcinolone (30 mg/day for 10 days), and minocycline hydrochloride (20 mg/day for 10 days) resulted in significant improvement. This rare case highlights the importance of accurate diagnosis and effective treatment strategies for the coexistence of PF and BP.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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