肠道菌群失调易引起血液感染。

IF 3.3 4区生物学 Q2 MICROBIOLOGY Journal of Microbiology Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI:10.1007/s12275-024-00190-5

Xiaomin Lin, Chun Lin, Xin Li, Fen Yao, Xiaoling Guo, Meimei Wang, Mi Zeng, Yumeng Yuan, Qingdong Xie, Xudong Huang, Xiaoyang Jiao

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引用次数: 0

摘要

目的：探讨肠道菌群在血流感染（bsi）发生中的作用。筛选42例患者和19例健康对照（hc），通过16S rRNA基因测序测定其肠道菌群。BSI组的细菌多样性明显低于hc组（P < 4）]，两组间差异有显著性。粪便微生物生态失调是BSI患者的常见情况。某些病原体的增殖或产生scfa的细菌的减少会导致对BSI的易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection.

To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.

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来源期刊

Journal of Microbiology 生物-微生物学

CiteScore

5.70

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Publishes papers that deal with research on microorganisms, including archaea, bacteria, yeasts, fungi, microalgae, protozoa, and simple eukaryotic microorganisms. Topics considered for publication include Microbial Systematics, Evolutionary Microbiology, Microbial Ecology, Environmental Microbiology, Microbial Genetics, Genomics, Molecular Biology, Microbial Physiology, Biochemistry, Microbial Pathogenesis, Host-Microbe Interaction, Systems Microbiology, Synthetic Microbiology, Bioinformatics and Virology. Manuscripts dealing with simple identification of microorganism(s), cloning of a known gene and its expression in a microbial host, and clinical statistics will not be considered for publication by JM.