出生后小鼠角膜发育的剪切波光学相干弹性成像及结构分析。

Andrew L Lopez, Mohammad Dehshiri, Alexander W Schill, Salavat Aglyamov, Kirill Larin
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引用次数: 0

摘要

角膜是位于眼睛最前端的透明晶状体,作为保护眼睛的结构屏障,并提供眼睛的大部分屈光能力。在这项研究中,我们利用出生后的小鼠眼睛来表征角膜结构和生物力学。从出生后第6天到第24天,我们观察到弹性波速度在第6天最高,在第24天逐渐下降,然后在成年期(6个月)开始上升。我们发现角膜厚度与弹性波速不耦合,角膜的含量和组织主要影响其力学性能。据我们所知,这项工作是对出生后小鼠角膜结构和生物力学的第一次详细评估,并保证进一步研究出生后眼睛的动态特性。
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Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea Through Development.

The cornea is a transparent lens at the forefront of the eye, serving as a structural barrier that protects the eye and provides the majority of the eye's refractive power. In this study, we utilized the postnatal mouse eye to characterize corneal structure and biomechanics. Between postnatal day (PN) 6 and PN24, we observed that elastic wave speeds are highest at PN6, gradually decrease through PN24, and then start to rise in adulthood (6 months). We found that corneal thickness is uncoupled from elastic wave speed and that the content and organization of the cornea primarily influence its mechanical properties. To the best of our knowledge, this work is the first detailed assessment of the postnatal mouse cornea's structure and biomechanics and warrants further investigation into the dynamic properties of the postnatal eye.

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