{"title":"功能化Carum cari衍生量子点（CcQDs）作为靶向小鼠CT26结肠癌肿瘤的放射性示踪剂的99mtc -放射性标记","authors":"Maryam Mazaheri Tehrani, Mostafa Erfani, Mostafa Guodarzi","doi":"10.1007/s10967-024-09810-1","DOIUrl":null,"url":null,"abstract":"<div><p>Carum carvi-derived quantum dots (CcQDs) were prepared using thermal pyrolyzing. The surface functionalization of CcQDs were achieved via L-cysteine ligand. Labeled CcQDs with technetium-99m were prepared using a simple direct radiolabeling method. Radio chromatographic techniques were used to analyze radiochemical yield. Quality control results indicated that QDs could be efficiently labeled with <sup>99m</sup>Tc-radionuclide (> 98% radiochemical yield). The in vivo biodistribution parameters were studied in tumorized BALB/c mouse. The amount of uptake in xenograft models of mice colon carcinoma was 1.27 ± 0.15% ID/g after 1 h. <sup>99m</sup>Tc-labeled T-Cysteine-CcQDs, could be included as a radiotracer for imaging colon carcinoma tumors.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"333 12","pages":"6415 - 6427"},"PeriodicalIF":1.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"99mTc-radiolabeling of a functionalized Carum carvi-derived quantum dots (CcQDs) as a new radiotracer for CT26 colon carcinoma tumor targeting in mouse\",\"authors\":\"Maryam Mazaheri Tehrani, Mostafa Erfani, Mostafa Guodarzi\",\"doi\":\"10.1007/s10967-024-09810-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Carum carvi-derived quantum dots (CcQDs) were prepared using thermal pyrolyzing. The surface functionalization of CcQDs were achieved via L-cysteine ligand. Labeled CcQDs with technetium-99m were prepared using a simple direct radiolabeling method. Radio chromatographic techniques were used to analyze radiochemical yield. Quality control results indicated that QDs could be efficiently labeled with <sup>99m</sup>Tc-radionuclide (> 98% radiochemical yield). The in vivo biodistribution parameters were studied in tumorized BALB/c mouse. The amount of uptake in xenograft models of mice colon carcinoma was 1.27 ± 0.15% ID/g after 1 h. <sup>99m</sup>Tc-labeled T-Cysteine-CcQDs, could be included as a radiotracer for imaging colon carcinoma tumors.</p></div>\",\"PeriodicalId\":661,\"journal\":{\"name\":\"Journal of Radioanalytical and Nuclear Chemistry\",\"volume\":\"333 12\",\"pages\":\"6415 - 6427\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radioanalytical and Nuclear Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10967-024-09810-1\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radioanalytical and Nuclear Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10967-024-09810-1","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
99mTc-radiolabeling of a functionalized Carum carvi-derived quantum dots (CcQDs) as a new radiotracer for CT26 colon carcinoma tumor targeting in mouse
Carum carvi-derived quantum dots (CcQDs) were prepared using thermal pyrolyzing. The surface functionalization of CcQDs were achieved via L-cysteine ligand. Labeled CcQDs with technetium-99m were prepared using a simple direct radiolabeling method. Radio chromatographic techniques were used to analyze radiochemical yield. Quality control results indicated that QDs could be efficiently labeled with 99mTc-radionuclide (> 98% radiochemical yield). The in vivo biodistribution parameters were studied in tumorized BALB/c mouse. The amount of uptake in xenograft models of mice colon carcinoma was 1.27 ± 0.15% ID/g after 1 h. 99mTc-labeled T-Cysteine-CcQDs, could be included as a radiotracer for imaging colon carcinoma tumors.
期刊介绍：
An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
