Synthesis of P(O)CH2N-substituted bis- and tris-phosphorus-containing amines

Convenient synthesis of P(O)CH₂N-substituted bis- and tris-phosphorus-containing amines using two- and three-component systems have been developed. Methods for the synthesis of new bis- and tris-aminomethylating reagents are presented. Esters of trivalent phosphorus acids react with paraformaldehyde, alkylamines or N-substituted bis(alkoxymethyl)amines, as well as tris(butoxymethyl)amine to give new P(O)CH₂N-substituted bis- and tris-phosphorus-containing amines. The resulting compounds are of interest as water-soluble polydentate ligands and effective extractants, as well as promising biologically active substances.