黄芪甲苷通过雌激素受体α抑制血管钙化。

IF 2.4 4区医学 Q3 GERIATRICS & GERONTOLOGY Geriatrics & Gerontology International Pub Date : 2024-12-05 DOI:10.1111/ggi.15032

Michiko Nanao-Hamai, Bo-Kyung Son, Sumito Ogawa, Masahiro Akishita

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引用次数: 0

摘要

黄芪甲苷（Astragaloside IV, As-IV）是日本传统虎仔补药的重要成分，具有类似雌激素的类固醇骨架。它通过雌激素受体α抑制血管钙化，对心血管有益。然而，它的雌激素样特性促进乳腺癌细胞增殖。需要有针对性的研究来优化心血管预防效果而不产生不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Astragaloside IV inhibits vascular calcification through estrogen receptor alpha

Astragaloside IV (As-IV), a key component of traditional Japanese Hozai tonics, has a steroid skeleton like estrogen. It inhibits vascular calcification via estrogen receptor α, offering cardiovascular benefits. However, its estrogen-like properties promote breast cancer cell proliferation. Targeted research is needed to optimize cardiovascular preventive effects without adverse effects.

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.