Pattara Rattanawong MD , Carolyn Mead-Harvey MS , Olubadewa A. Fatunde MD, MPH , Charles Van Der Walt , Nway Ko Ko MBBS , Patrick Hooke MD , Thanaboon Yinadsawaphan MD , Narathorn Kulthamrongsri MD , Win-Kuang Shen MD , Dan Sorajja MD
{"title":"1型Brugada型的患病率和发病率：梅奥诊所30年的经验。","authors":"Pattara Rattanawong MD , Carolyn Mead-Harvey MS , Olubadewa A. Fatunde MD, MPH , Charles Van Der Walt , Nway Ko Ko MBBS , Patrick Hooke MD , Thanaboon Yinadsawaphan MD , Narathorn Kulthamrongsri MD , Win-Kuang Shen MD , Dan Sorajja MD","doi":"10.1016/j.mayocp.2024.05.028","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To identify the incidence and prevalence of type 1 Brugada pattern at Mayo Clinic during 30 years.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the electronic medical records from 1992 to 2021 at Mayo Clinic Enterprise. Patients with type 1 Brugada pattern electrocardiogram (ECG) were identified by a systematic keyword search. Incidences are calculated by decade. The incidence rate ratios (IRRs) between races were then calculated. Analysis of the association between groups and major arrhythmic event–free survival was conducted.</div></div><div><h3>Results</h3><div>The study analyzed 5,381,186 ECGs from 2,304,809 patients; 150 patients had at least 1 ECG with a type 1 Brugada pattern (76.0% Brugada syndrome, 62.0% spontaneous, 18.7% fever induced, and 10.7% drug induced). The mean follow-up was 6.6±6.7 years. The incidence (per 100,000 person-years) of type 1 Brugada pattern increased during the past 3 decades (0.505 [95% CI, 0.203 to 1.040], 3.015 [95% CI, 2.272 to 3.925], and 3.916 [95% CI, 3.128 to 4.842]). The incidence in Black patients was approximately 1.5-fold higher compared with non-Hispanic White patients (IRR, 1.492 [95% CI, 0.610 to 3.649]; <em>P</em>=.38). The incidence in Hispanic White patients was 3-fold higher than in non-Hispanic White patients (IRR, 3.021 [95% CI, 1.410 to 6.474]; <em>P</em>=.005). The incidence in Asian patients was 2-fold higher than in Hispanic patients (IRR, 1.894 [95% CI, 0.705 to 5.086]; <em>P</em>=.21). The overall prevalence of the type 1 Brugada pattern between 2010 and 2021 was 10.094 per 100,000. The major arrhythmic events occurred in 8.6%, 7.1%, 12.5%, and 7.7% for spontaneous, fever-induced, drug-induced, and other type 1 Brugada patterns, respectively, during follow-up.</div></div><div><h3>Conclusion</h3><div>The incidence of type 1 Brugada pattern at Mayo Clinic has increased during 3 decades. The prevalence of type 1 Brugada pattern in the United States is higher than previously reported. Type 1 Brugada pattern in Black and Hispanic populations is more common than previously suspected.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"100 1","pages":"Pages 80-93"},"PeriodicalIF":6.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and Incidence of Type 1 Brugada Pattern: A 30-Year Experience at Mayo Clinic\",\"authors\":\"Pattara Rattanawong MD , Carolyn Mead-Harvey MS , Olubadewa A. Fatunde MD, MPH , Charles Van Der Walt , Nway Ko Ko MBBS , Patrick Hooke MD , Thanaboon Yinadsawaphan MD , Narathorn Kulthamrongsri MD , Win-Kuang Shen MD , Dan Sorajja MD\",\"doi\":\"10.1016/j.mayocp.2024.05.028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To identify the incidence and prevalence of type 1 Brugada pattern at Mayo Clinic during 30 years.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the electronic medical records from 1992 to 2021 at Mayo Clinic Enterprise. Patients with type 1 Brugada pattern electrocardiogram (ECG) were identified by a systematic keyword search. Incidences are calculated by decade. The incidence rate ratios (IRRs) between races were then calculated. Analysis of the association between groups and major arrhythmic event–free survival was conducted.</div></div><div><h3>Results</h3><div>The study analyzed 5,381,186 ECGs from 2,304,809 patients; 150 patients had at least 1 ECG with a type 1 Brugada pattern (76.0% Brugada syndrome, 62.0% spontaneous, 18.7% fever induced, and 10.7% drug induced). The mean follow-up was 6.6±6.7 years. The incidence (per 100,000 person-years) of type 1 Brugada pattern increased during the past 3 decades (0.505 [95% CI, 0.203 to 1.040], 3.015 [95% CI, 2.272 to 3.925], and 3.916 [95% CI, 3.128 to 4.842]). The incidence in Black patients was approximately 1.5-fold higher compared with non-Hispanic White patients (IRR, 1.492 [95% CI, 0.610 to 3.649]; <em>P</em>=.38). The incidence in Hispanic White patients was 3-fold higher than in non-Hispanic White patients (IRR, 3.021 [95% CI, 1.410 to 6.474]; <em>P</em>=.005). The incidence in Asian patients was 2-fold higher than in Hispanic patients (IRR, 1.894 [95% CI, 0.705 to 5.086]; <em>P</em>=.21). The overall prevalence of the type 1 Brugada pattern between 2010 and 2021 was 10.094 per 100,000. The major arrhythmic events occurred in 8.6%, 7.1%, 12.5%, and 7.7% for spontaneous, fever-induced, drug-induced, and other type 1 Brugada patterns, respectively, during follow-up.</div></div><div><h3>Conclusion</h3><div>The incidence of type 1 Brugada pattern at Mayo Clinic has increased during 3 decades. The prevalence of type 1 Brugada pattern in the United States is higher than previously reported. Type 1 Brugada pattern in Black and Hispanic populations is more common than previously suspected.</div></div>\",\"PeriodicalId\":18334,\"journal\":{\"name\":\"Mayo Clinic proceedings\",\"volume\":\"100 1\",\"pages\":\"Pages 80-93\"},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mayo Clinic proceedings\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0025619624003033\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mayo Clinic proceedings","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0025619624003033","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Prevalence and Incidence of Type 1 Brugada Pattern: A 30-Year Experience at Mayo Clinic
Objective
To identify the incidence and prevalence of type 1 Brugada pattern at Mayo Clinic during 30 years.
Methods
We retrospectively reviewed the electronic medical records from 1992 to 2021 at Mayo Clinic Enterprise. Patients with type 1 Brugada pattern electrocardiogram (ECG) were identified by a systematic keyword search. Incidences are calculated by decade. The incidence rate ratios (IRRs) between races were then calculated. Analysis of the association between groups and major arrhythmic event–free survival was conducted.
Results
The study analyzed 5,381,186 ECGs from 2,304,809 patients; 150 patients had at least 1 ECG with a type 1 Brugada pattern (76.0% Brugada syndrome, 62.0% spontaneous, 18.7% fever induced, and 10.7% drug induced). The mean follow-up was 6.6±6.7 years. The incidence (per 100,000 person-years) of type 1 Brugada pattern increased during the past 3 decades (0.505 [95% CI, 0.203 to 1.040], 3.015 [95% CI, 2.272 to 3.925], and 3.916 [95% CI, 3.128 to 4.842]). The incidence in Black patients was approximately 1.5-fold higher compared with non-Hispanic White patients (IRR, 1.492 [95% CI, 0.610 to 3.649]; P=.38). The incidence in Hispanic White patients was 3-fold higher than in non-Hispanic White patients (IRR, 3.021 [95% CI, 1.410 to 6.474]; P=.005). The incidence in Asian patients was 2-fold higher than in Hispanic patients (IRR, 1.894 [95% CI, 0.705 to 5.086]; P=.21). The overall prevalence of the type 1 Brugada pattern between 2010 and 2021 was 10.094 per 100,000. The major arrhythmic events occurred in 8.6%, 7.1%, 12.5%, and 7.7% for spontaneous, fever-induced, drug-induced, and other type 1 Brugada patterns, respectively, during follow-up.
Conclusion
The incidence of type 1 Brugada pattern at Mayo Clinic has increased during 3 decades. The prevalence of type 1 Brugada pattern in the United States is higher than previously reported. Type 1 Brugada pattern in Black and Hispanic populations is more common than previously suspected.
期刊介绍：
Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.
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