{"title":"多组学整合空间蛋白质分析","authors":"Rong Fan","doi":"10.1038/s41592-024-02533-x","DOIUrl":null,"url":null,"abstract":"Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular function, heterogeneity and interactions, and the underlying mechanisms of these processes. I highlight current challenges and emerging opportunities for multi-omic spatial protein profiling to advance basic research and translational applications.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2223-2225"},"PeriodicalIF":36.1000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Integrative spatial protein profiling with multi-omics\",\"authors\":\"Rong Fan\",\"doi\":\"10.1038/s41592-024-02533-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular function, heterogeneity and interactions, and the underlying mechanisms of these processes. I highlight current challenges and emerging opportunities for multi-omic spatial protein profiling to advance basic research and translational applications.\",\"PeriodicalId\":18981,\"journal\":{\"name\":\"Nature Methods\",\"volume\":\"21 12\",\"pages\":\"2223-2225\"},\"PeriodicalIF\":36.1000,\"publicationDate\":\"2024-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Methods\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41592-024-02533-x\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-024-02533-x","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Integrative spatial protein profiling with multi-omics
Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular function, heterogeneity and interactions, and the underlying mechanisms of these processes. I highlight current challenges and emerging opportunities for multi-omic spatial protein profiling to advance basic research and translational applications.
期刊介绍：
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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