在接受持久左心室辅助装置的患者中，泵交换对主要装置相关感染的影响。

IF 6.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Heart and Lung Transplantation Pub Date : 2024-12-04 DOI:10.1016/j.healun.2024.11.032

Sophie R Persaud, Michael Pienta, Donald S Likosky, Francis D Pagani

{"title":"在接受持久左心室辅助装置的患者中，泵交换对主要装置相关感染的影响。","authors":"Sophie R Persaud, Michael Pienta, Donald S Likosky, Francis D Pagani","doi":"10.1016/j.healun.2024.11.032","DOIUrl":null,"url":null,"abstract":"Background: Device-related infection (DRI) remains a cause of morbidity and mortality following durable left ventricular assist device (dLVAD) implantation. We evaluated outcomes following pump exchange (PE) for DRI following dLVAD implantation.Methods: Forty-nine patients underwent PE between 1/2007 and 12/2022 for major DRI. Outcomes included survival, incidence of subsequent DRI, and proportion of patients achieving success (freedom from DRI at 1-year following PE).Results: Median age was 49 years. Median time from primary implant to DRI diagnosis and from diagnosis to PE was 26 and 4.1 months, respectively. Median time to DRI recurrence was 5.8 months with 76% of patients achieving success. Success was obtained in 23/24 (96%) of patients whose time to PE from DRI diagnosis was ≤4 months and 14/25 (56%) if time >4 months.Conclusion: Most patients achieve success following PE for DRI. The risk of subsequent DRI and mortality remains high. Early (≤4 months) PE following DRI diagnosis increases the likelihood of success, while reducing the rate of subsequent DRI.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pump exchange for major device related infection in patients receiving a durable left ventricular assist device.\",\"authors\":\"Sophie R Persaud, Michael Pienta, Donald S Likosky, Francis D Pagani\",\"doi\":\"10.1016/j.healun.2024.11.032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Device-related infection (DRI) remains a cause of morbidity and mortality following durable left ventricular assist device (dLVAD) implantation. We evaluated outcomes following pump exchange (PE) for DRI following dLVAD implantation.Methods: Forty-nine patients underwent PE between 1/2007 and 12/2022 for major DRI. Outcomes included survival, incidence of subsequent DRI, and proportion of patients achieving success (freedom from DRI at 1-year following PE).Results: Median age was 49 years. Median time from primary implant to DRI diagnosis and from diagnosis to PE was 26 and 4.1 months, respectively. Median time to DRI recurrence was 5.8 months with 76% of patients achieving success. Success was obtained in 23/24 (96%) of patients whose time to PE from DRI diagnosis was ≤4 months and 14/25 (56%) if time >4 months.Conclusion: Most patients achieve success following PE for DRI. The risk of subsequent DRI and mortality remains high. Early (≤4 months) PE following DRI diagnosis increases the likelihood of success, while reducing the rate of subsequent DRI.\",\"PeriodicalId\":15900,\"journal\":{\"name\":\"Journal of Heart and Lung Transplantation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.4000,\"publicationDate\":\"2024-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heart and Lung Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.healun.2024.11.032\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heart and Lung Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.healun.2024.11.032","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

背景：器械相关感染（DRI）仍然是持久左心室辅助装置（dLVAD）植入后发病和死亡的一个原因。我们评估了dLVAD植入后DRI的泵交换（PE）的结果。方法：49例重度DRI患者于2007年1月至2022年12月期间接受了PE治疗。结果包括生存率、后续DRI的发生率和获得成功的患者比例（PE后1年无DRI）。结果：中位年龄49岁。从首次植入到DRI诊断和从诊断到PE的中位时间分别为26个月和4.1个月。DRI复发的中位时间为5.8个月，76%的患者获得成功。从DRI诊断到PE时间≤4个月的患者中，有23/24（96%）成功，而时间≤4个月的患者中有14/25（56%）成功。结论：大多数DRI患者在PE治疗后获得成功。随后发生DRI和死亡率的风险仍然很高。DRI诊断后早期（≤4个月）PE增加了成功的可能性，同时降低了随后DRI的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Pump exchange for major device related infection in patients receiving a durable left ventricular assist device.

Background: Device-related infection (DRI) remains a cause of morbidity and mortality following durable left ventricular assist device (dLVAD) implantation. We evaluated outcomes following pump exchange (PE) for DRI following dLVAD implantation.

Methods: Forty-nine patients underwent PE between 1/2007 and 12/2022 for major DRI. Outcomes included survival, incidence of subsequent DRI, and proportion of patients achieving success (freedom from DRI at 1-year following PE).

Results: Median age was 49 years. Median time from primary implant to DRI diagnosis and from diagnosis to PE was 26 and 4.1 months, respectively. Median time to DRI recurrence was 5.8 months with 76% of patients achieving success. Success was obtained in 23/24 (96%) of patients whose time to PE from DRI diagnosis was ≤4 months and 14/25 (56%) if time >4 months.

Conclusion: Most patients achieve success following PE for DRI. The risk of subsequent DRI and mortality remains high. Early (≤4 months) PE following DRI diagnosis increases the likelihood of success, while reducing the rate of subsequent DRI.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Heart and Lung Transplantation 医学-呼吸系统

CiteScore

10.10

自引率

6.70%

发文量

1667

审稿时长

69 days

期刊介绍： The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.