{"title":"胃肠道微生物组在类风湿关节炎、银屑病关节炎、强直性脊柱炎和反应性关节炎中的作用：系统综述。","authors":"Beverly Cheok Kuan Ng, Marissa Lassere","doi":"10.1016/j.semarthrit.2024.152574","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is an increasing body of literature observing a state of dysbiosis in the gut microbiome in different autoimmune conditions including inflammatory arthritis. It is unknown whether the microbiome can be a biomarker for prognostication purposes or for stratification of treatment strategies. This review aims to evaluate the existing evidence on the association between the microbiome and inflammatory arthritis, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) and reactive arthritis (ReA) population groups.</p><p><strong>Methods: </strong>This systematic review was performed based on methods from the Cochrane guidelines and reported based on PRISMA criteria. Studies exploring the microbiome of patients with RA, AS, PsA or ReA compared with controls via 16s rRNA or shotgun sequencing were evaluated. The outcomes of interest include alpha and beta diversity, abundance or depletion of organisms and functional analysis. Literature up to August 2024 was retrieved searching the databases PubMed, Medline, ScienceDirect, Scopus, Web of Science, Cochrane, EMBASE and CINAHL. All references were systematically evaluated by two reviewers. Quality of the studies were evaluated by the Newcastle-Ottawa Scale.</p><p><strong>Findings: </strong>The review yielded 25,794 search results, of which 53 studies were included for the RA group, 34 studies for the AS group, 6 studies for the PsA group and 2 studies for the ReA group. Reduced diversity has been observed in disease groups and in patients with higher disease activity.</p><p><strong>Interpretation: </strong>There are limited longitudinal studies on the role of the microbiome in inflammatory arthritis, in particular PsA. Existing cross-sectional studies suggest altered microbiome in disease states compared with controls. Further studies are required to understand the utility of the microbiome as a biomarker to better understand prognosis and tailor treatments.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"70 ","pages":"152574"},"PeriodicalIF":4.6000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of the gastrointestinal microbiome on rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and reactive arthritis: A systematic review.\",\"authors\":\"Beverly Cheok Kuan Ng, Marissa Lassere\",\"doi\":\"10.1016/j.semarthrit.2024.152574\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is an increasing body of literature observing a state of dysbiosis in the gut microbiome in different autoimmune conditions including inflammatory arthritis. 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引用次数: 0
摘要
背景：越来越多的文献观察到不同自身免疫性疾病（包括炎症性关节炎）中肠道微生物群的生态失调状态。目前尚不清楚微生物组是否可以作为预测目的或治疗策略分层的生物标志物。本综述旨在评价微生物组与炎性关节炎（包括类风湿关节炎（RA）、银屑病关节炎（PsA）、强直性脊柱炎（AS）和反应性关节炎（ReA）人群）之间关系的现有证据。方法：本系统综述基于Cochrane指南的方法，并根据PRISMA标准进行报道。通过16s rRNA或霰弹枪测序对RA、AS、PsA或ReA患者的微生物组进行了研究，并与对照组进行了比较。感兴趣的结果包括α和β多样性，生物体的丰度或损耗以及功能分析。检索PubMed、Medline、ScienceDirect、Scopus、Web of Science、Cochrane、EMBASE和CINAHL数据库，检索截至2024年8月的文献。所有参考文献均由两位审稿人系统评估。研究的质量采用纽卡斯尔-渥太华量表进行评估。结果：本综述共获得25,794项检索结果，其中RA组53项，AS组34项，PsA组6项，ReA组2项。在疾病组和疾病活动度较高的患者中观察到多样性减少。解释：关于微生物组在炎症性关节炎中的作用的纵向研究有限，特别是PsA。现有的横断面研究表明，与对照组相比，疾病状态下的微生物组发生了改变。需要进一步的研究来了解微生物组作为生物标志物的效用，以更好地了解预后和定制治疗。
The role of the gastrointestinal microbiome on rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and reactive arthritis: A systematic review.
Background: There is an increasing body of literature observing a state of dysbiosis in the gut microbiome in different autoimmune conditions including inflammatory arthritis. It is unknown whether the microbiome can be a biomarker for prognostication purposes or for stratification of treatment strategies. This review aims to evaluate the existing evidence on the association between the microbiome and inflammatory arthritis, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) and reactive arthritis (ReA) population groups.
Methods: This systematic review was performed based on methods from the Cochrane guidelines and reported based on PRISMA criteria. Studies exploring the microbiome of patients with RA, AS, PsA or ReA compared with controls via 16s rRNA or shotgun sequencing were evaluated. The outcomes of interest include alpha and beta diversity, abundance or depletion of organisms and functional analysis. Literature up to August 2024 was retrieved searching the databases PubMed, Medline, ScienceDirect, Scopus, Web of Science, Cochrane, EMBASE and CINAHL. All references were systematically evaluated by two reviewers. Quality of the studies were evaluated by the Newcastle-Ottawa Scale.
Findings: The review yielded 25,794 search results, of which 53 studies were included for the RA group, 34 studies for the AS group, 6 studies for the PsA group and 2 studies for the ReA group. Reduced diversity has been observed in disease groups and in patients with higher disease activity.
Interpretation: There are limited longitudinal studies on the role of the microbiome in inflammatory arthritis, in particular PsA. Existing cross-sectional studies suggest altered microbiome in disease states compared with controls. Further studies are required to understand the utility of the microbiome as a biomarker to better understand prognosis and tailor treatments.
期刊介绍：
Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.
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