类风湿关节炎关节中的DC-T细胞能量偶联

IF 25.5 1区医学 Q1 IMMUNOLOGY Immunity Pub Date : 2024-12-10 DOI:10.1016/j.immuni.2024.11.012

Kazuhiko Higashioka, Deepak A. Rao

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引用次数: 0

摘要

类风湿性关节炎（RA）是由靶向关节的抗原特异性T细胞反应驱动的。MacDonald等人1定义了RA患者关节内树突状细胞（DC）群的范围，并强调了炎症RA滑膜中富集的特定iDC3和DC2群，这些iDC3和DC2群促进了T细胞的激活，以及RA中丢失的健康滑膜中的耐受性AXL+ DC2s。

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DC-T cell power couples in rheumatoid arthritis joints

Rheumatoid arthritis (RA) is driven by antigen-specific T cell responses targeting the joints. MacDonald et al.¹ define the range of dendritic cell (DC) populations within joints of RA patients and highlight specific iDC3 and DC2 populations enriched in inflamed RA synovium that promote T cell activation as well as tolerogenic AXL⁺ DC2s in healthy synovium that are lost in RA.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.