IF 2 4区 医学 Q3 NUTRITION & DIETETICS Nutrition Research and Practice Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI:10.4162/nrp.2024.18.6.793
Hyun Hwangbo, Hee-Jae Cha, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Jeong Sook Noh, Tae Hee Kim, Heui-Soo Kim, Sung-Kwon Moon, Gi-Young Kim, Yung Hyun Choi
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引用次数: 0

摘要

背景/目的:良性前列腺增生症(BPH)是老年男性的一种常见疾病,最近,草药在治疗良性前列腺增生症(BPH)方面受到了关注。在这项研究中,我们利用睾酮诱导的良性前列腺增生模型,旨在确定传统上用于治疗各种疾病的天冬(Asparagi radix,EAR)乙醇提取物对良性前列腺增生发展的影响:材料/方法: 使用丙酸睾酮(TP)处理的 Sprague-Dawley 大鼠在体内建立良性前列腺增生模型。EAR与TP同时口服,非那雄胺作为阳性对照。实验结束后处死所有大鼠,评估前列腺组织的病理变化以及与良性前列腺增生症发病机制相关的关键生物标志物的水平:结果:口服EAR能明显抑制TP诱导的良性前列腺增生症,因为它能以浓度依赖的方式降低前列腺重量、管腔大小和上皮厚度。EAR 还能明显抑制 TP 诱导的 5α 还原酶 2 型 (SRD5A2)、增殖细胞核抗原和前列腺特异性抗原 (PSA) 的表达。此外,TP 诱导组的血清睾酮、双氢睾酮和 PSA 水平升高,而 EAR 治疗组的血清睾酮、双氢睾酮和 PSA 水平下降。EAR 还能降低 TP 诱导的良性前列腺增生模型大鼠体内雄激素受体(AR)及其辅助激活剂的表达水平:我们的研究结果表明,EAR能通过抑制5α-还原酶活性和AR信号通路来预防良性前列腺增生症,这表明它具有治疗良性前列腺增生症的潜力。
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Asparagi radix alleviates testosterone-induced benign prostatic hyperplasia by inhibiting 5α-reductase activity and androgen receptor signaling pathway.

Background/objectives: Recently, herbal medicines have gained attention for the treatment of benign prostatic hyperplasia (BPH), a common disease in elderly men. In this study, we aimed to determine the effect of ethanol extract of Asparagi radix (EAR), which is traditionally used to treat various diseases, on BPH development using a testosterone-induced BPH model.

Materials/methods: Testosterone propionate (TP)-treated Sprague-Dawley rats were used to establish a BPH model in vivo. EAR was orally administered along with TP, and finasteride was used as a positive control. All rats were sacrificed at the end of the experiment, and pathological changes in the prostate tissue and levels of key biomarkers associated with BPH pathogenesis were assessed.

Results: Oral administration of EAR significantly inhibited TP-induced BPH by reducing the prostate weight, lumen size, and epithelial thickness in a concentration-dependent manner. EAR also significantly abrogated the expression of 5α-reductase type 2 (SRD5A2), proliferating cell nuclear antigen, and prostate-specific antigen (PSA) induced by TP. Additionally, serum levels of testosterone, dihydrotestosterone, and PSA were elevated in the TP-induced group but decreased in the EAR-treated group. EAR also decreased the expression levels of the androgen receptor (AR) and its coactivators in TP-induced BPH model rats.

Conclusion: Our findings revealed that EAR protected against BPH by inhibiting 5α-reductase activity and AR signaling pathway, suggesting its potential for BPH treatment.

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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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