肾母细胞瘤和相关的易感综合征和条件。

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI:10.1097/01.JAA.0000000000000165
David Meni
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引用次数: 0

摘要

摘要:肾母细胞瘤(Wilms tumor)又称肾母细胞瘤(nephroblastoma),是一种较为罕见但最常见的儿童肾脏恶性肿瘤,约占所有儿童恶性肿瘤的5%,占所有儿童肾脏恶性肿瘤的90%。随着对肾母细胞瘤病因和病理生理的深入了解,儿童肾母细胞瘤的预后和生存率显著提高,但病例可能是偶发的,某些患者的复发率和发病率较高。最常见的临床表现包括腹部肿块或肿胀,无其他体征或症状。可能出现的症状的非特异性会延迟及时诊断和治疗。许多易感综合征与肾母细胞瘤发展的风险增加有关。认识到这些症状和其他情况并了解其增加的风险的临床医生可以提供适当水平的预期指导并使用最佳筛查计划。
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Wilms tumor and associated predisposing syndromes and conditions.

Abstract: Wilms tumor, also known as nephroblastoma, is relatively rare but is the most common renal malignancy in children, accounting for about 5% of all childhood malignancies and 90% of all childhood renal malignancies. Advances in the understanding of the underlying cause and pathophysiology of Wilms tumor have significantly improved the prognosis and survival rates for children with Wilms tumor, but cases may occur sporadically and certain affected patients face higher rates of relapse and morbidity. The most common clinical presentation involves the identification of an abdominal mass or swelling without other signs or symptoms. The nonspecific nature of symptoms that can present can delay timely diagnosis and treatment. Numerous predisposing syndromes are associated with an increased risk for the development of Wilms tumor. Clinicians who recognize these syndromes and other conditions and understand the increased risk can provide the appropriate level of anticipatory guidance and use the optimal screening plan.

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来源期刊
CiteScore
1.20
自引率
9.10%
发文量
310
期刊介绍: ​​​JAAPA is the peer-reviewed clinical journal of the American Academy of Physician Assistants (AAPA). Published for more than 25 years, its mission is to support the ongoing education and advancement of physician assistants (PAs) by publishing current information and research on clinical, health policy, and professional issues. Published monthly, JAAPA''s award-winning editorial includes: -Clinical review articles (with AAPA-approved Category I CME in each issue)- Case reports- Clinical departments- Original health services research- Articles on issues of professional interest to PAs
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