A mechanistic understanding of human magnetoreception validates the phenomenon of electromagnetic hypersensitivity (EHS).

Background: Human electromagnetic hypersensitivity (EHS) or electrosensitivity (ES) symptoms in response to anthropogenic electromagnetic fields (EMFs) at levels below current international safety standards are generally considered to be nocebo effects by conventional medical science. In the wider field of magnetoreception in biology, our understanding of mechanisms and processes of magnetic field (MF) interactions is more advanced.

Methods: We consulted a range of publication databases to identify the key advances in understanding of magnetoreception across the wide animal kingdom of life.

Results: We examined primary MF/EMF sensing and subsequent coupling to the nervous system and the brain. Magnetite particles in our brains and other tissues can transduce MFs/EMFs, including at microwave frequencies. The radical pair mechanism (RPM) is accepted as the main basis of the magnetic compass in birds and other species, acting via cryptochrome protein molecules in the eye. In some cases, extraordinary sensitivity is observed, several thousand times below that of the geomagnetic field. Bird compass disorientation by radio frequency (RF) EMFs is known.

Conclusions: Interdisciplinary research has established that all forms of life can respond to MFs. Research shows that human cryptochromes exhibit magnetosensitivity. Most existing provocation studies have failed to confirm EHS as an environmental illness. We attribute this to a fundamental lack of understanding of the mechanisms and processes involved, which have resulted in the design of inappropriate and inadequate tests. We conclude that future research into EHS needs a quantum mechanistic approach on the basis of existing biological knowledge of the magnetosensitivity of living organisms.