Zixiao Wang, Xingchen Dong, Yashao Chen, Changhao Wang
{"title":"对映选择性反应的四重DNA杂化催化剂。","authors":"Zixiao Wang, Xingchen Dong, Yashao Chen, Changhao Wang","doi":"10.1002/cbic.202400909","DOIUrl":null,"url":null,"abstract":"<p><p>Beyond the pivotal genetic roles of DNA, its duplex structures as chiral scaffolds interacting with metal complexes give rise to DNA hybrid catalysts for a set of aqueous-phase enantioselective reactions. Besides DNA duplex, DNA quadruplexes including G-quadruplex and i-motif show tunable structures with variable non-canonical base pairs. In this concept, based on the interaction between metal species and DNA, we classify the construction strategies of quadruplex DNA hybrid catalysts into supramolecular, covalent and coordinative modes. Furthermore, we analyze the relationship between DNA quadruplexes and their enantioselective catalytic performance. Finally, we summarize the current challenges and look forward to the future directions in DNA-based enantioselective catalysis.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202400909"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quadruplex DNA Hybrid Catalysts for Enantioselective Reactions.\",\"authors\":\"Zixiao Wang, Xingchen Dong, Yashao Chen, Changhao Wang\",\"doi\":\"10.1002/cbic.202400909\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Beyond the pivotal genetic roles of DNA, its duplex structures as chiral scaffolds interacting with metal complexes give rise to DNA hybrid catalysts for a set of aqueous-phase enantioselective reactions. Besides DNA duplex, DNA quadruplexes including G-quadruplex and i-motif show tunable structures with variable non-canonical base pairs. In this concept, based on the interaction between metal species and DNA, we classify the construction strategies of quadruplex DNA hybrid catalysts into supramolecular, covalent and coordinative modes. Furthermore, we analyze the relationship between DNA quadruplexes and their enantioselective catalytic performance. Finally, we summarize the current challenges and look forward to the future directions in DNA-based enantioselective catalysis.</p>\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\" \",\"pages\":\"e202400909\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1002/cbic.202400909\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202400909","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Quadruplex DNA Hybrid Catalysts for Enantioselective Reactions.
Beyond the pivotal genetic roles of DNA, its duplex structures as chiral scaffolds interacting with metal complexes give rise to DNA hybrid catalysts for a set of aqueous-phase enantioselective reactions. Besides DNA duplex, DNA quadruplexes including G-quadruplex and i-motif show tunable structures with variable non-canonical base pairs. In this concept, based on the interaction between metal species and DNA, we classify the construction strategies of quadruplex DNA hybrid catalysts into supramolecular, covalent and coordinative modes. Furthermore, we analyze the relationship between DNA quadruplexes and their enantioselective catalytic performance. Finally, we summarize the current challenges and look forward to the future directions in DNA-based enantioselective catalysis.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
