人类微生物群与疥疮的因果关系：从遗传学角度的研究。

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S491660

Qi Zheng, Yuetong Li, Wenfeng Zhu, Xiang Xu, Guoping Sheng, Lanjuan Li

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引用次数: 0

摘要

背景：以往的研究表明，人类菌群可能影响疥疮的发展，但没有研究证明人类菌群与疥疮之间存在因果关系，这将不利于未来对人类菌群与疥疮的深入研究。方法：采用孟德尔随机化（Mendelian randomization， MR）方法分析人类微生物群与疥疮之间的因果关系，数据来自两项大型已发表研究的肠道菌群和皮肤菌群，疥疮数据来自FinnGen数据库。采用5种MR分析方法提高结果的可靠性，并进行敏感性分析以提高结果的稳健性。结果：13种肠道菌群和7种皮肤菌群可能与疥疮有因果关系。结论：总的来说，我们的研究结果表明肠道和皮肤菌群与疥疮之间存在因果关系，并且与先前的观察结果一致。这将有助于未来开发用于预防或治疗疥疮的益生菌制剂。

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The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective.

Background: Previous studies have indicated that human flora may affect the development of scabies, however, no studies have proven a causal relationship between human flora and scabies, which would be detrimental to future in-depth studies on human flora and scabies.

Methods: Mendelian randomization (MR) was used to analyze the causal effect between human microbiota and scabies, with data on intestinal flora and skin flora from two large published studies and data on scabies from the FinnGen database. Five MR analysis methods were used to increase the reliability of the results, and sensitivity analyses were conducted to increase the robustness of the results.

Results: Our results suggest that 13 intestinal flora as well as 7 skin flora can have a causal effect on scabies.

Conclusion: Overall, our results demonstrate a causal relationship between intestinal and skin flora and scabies and are consistent with previous observational findings. This will contribute to the future development of probiotic agents for the prevention or treatment of scabies.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.