R. Della Loggia , E. Ragazzi , A. Tubaro , G. Fassina , R. Vertua
{"title":"环氧化酶和脂氧化酶抑制剂苯并吡酮类药物的抗炎活性","authors":"R. Della Loggia , E. Ragazzi , A. Tubaro , G. Fassina , R. Vertua","doi":"10.1016/S0031-6989(88)80849-X","DOIUrl":null,"url":null,"abstract":"<div><p>The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NOGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 91-94"},"PeriodicalIF":0.0000,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80849-X","citationCount":"39","resultStr":"{\"title\":\"Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase\",\"authors\":\"R. Della Loggia , E. Ragazzi , A. Tubaro , G. Fassina , R. Vertua\",\"doi\":\"10.1016/S0031-6989(88)80849-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NOGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.</p></div>\",\"PeriodicalId\":19810,\"journal\":{\"name\":\"Pharmacological research communications\",\"volume\":\"20 \",\"pages\":\"Pages 91-94\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80849-X\",\"citationCount\":\"39\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S003169898880849X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S003169898880849X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase
The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NOGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.
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