柯萨奇B族病毒感染动物模型的研究进展及应用前景

IF 8.4 2区医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2024-12-22 DOI:10.1080/22221751.2024.2441391

Shihan Weng, Rui Zhu, Yuanyuan Wu, Ningshao Xia, Longfa Xu, Tong Cheng

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引用次数: 0

摘要

B组柯萨奇病毒（CVBs）包括CVB1 ~ CVB6 6种血清型，临床可累及心、脑、肝、胰腺等脏器，引起心肌炎、脑炎、脊髓炎、胰腺炎、手足口病等疾病，甚至可致人死亡。CVBs在全球范围内广泛存在，并且具有高度传染性。然而，目前还没有批准的CVB疫苗或有效的治疗方法。动物模型的构建和优化将有助于深入了解CVB感染及其发病机制，为探索疫苗开发和抗病毒治疗提供重要工具。本文综述了CVB动物模型的最新研究进展及应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress and application prospects of animal models of group B Coxsackievirus infections.

Group B Coxsackieviruses (CVBs) consist of six serotypes, CVB1 to CVB6, which can clinically affect the heart, brain, liver, pancreas and other organs, causing myocarditis, encephalitis, myelitis, pancreatitis, hand-foot-and-mouth disease (HFMD) and other diseases, and can even lead to death. CVBs are widespread globally and highly contagious. However, there are currently no approved CVB vaccines or effective treatments. The construction and optimization of animal models will aid in the in-depth understanding of CVB infections and its pathogenesis, providing essential tools for the exploration of vaccine development and antiviral therapies. This paper reviews the latest research progress and application prospects of CVB animal models.

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.