肾结石的发生机制:微生物群是否起作用?

IF 4.8 2区 医学 Q1 UROLOGY & NEPHROLOGY European urology focus Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI:10.1016/j.euf.2024.11.010
Jose Agudelo, Sromona Mukherjee, Mangesh Suryavanshi, Bernardita Ljubetic, Marcelo Mass Lindenbaum, Aaron W Miller
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引用次数: 0

摘要

肾结石在世界各地造成了重大的卫生保健负担。在过去的十年中,人们对人类微生物群与肾结石发病的关系产生了相当大的兴趣。大多数研究都集中在肠道细菌对草酸盐的降解上,草酸盐是肾结石的已知致病因素。最近,抗生素暴露的作用和短链脂肪酸的变化已经被研究。研究表明,泌尿道,以前被认为是无菌的,窝藏着与肾结石密切相关的常驻微生物群落。在这篇小型综述中,我们评估了微生物群在肾结石发病中的潜在致病作用,以及预防这种疾病的新疗法的发展。患者总结:这篇小型综述讨论了肠道和泌尿道中细菌对肾结石形成影响的科学证据。我们讨论了针对这些细菌的可能的治疗方法,可以防止肾结石的形成。
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Mechanism of Nephrolithiasis: Does the Microbiome Play a Role?

Nephrolithiasis imposes a significant health care burden around the world. In the past decade, there has been considerable interest in the human microbiota in relation to the onset of nephrolithiasis. Most of the research has focused on degradation of oxalate, a known causative factor for nephrolithiasis, by bacteria in the gut. More recently, the role of antibiotic exposure and changes to short-chain fatty acids have been investigated. Studies have revealed that the urinary tract, previously thought to be sterile, harbors resident microbial communities closely associated with nephrolithiasis. In this mini-review, we evaluate potential causative roles of the microbiome in the onset of nephrolithiasis and the development of novel therapies to prevent this disease. PATIENT SUMMARY: This mini-review discusses scientific evidence on the influence of bacteria in our intestines and urinary tract on the formation of kidney stones. We discuss possible therapies targeting these bacteria that could prevent kidney stones from forming.

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来源期刊
European urology focus
European urology focus Medicine-Urology
CiteScore
10.40
自引率
3.70%
发文量
274
审稿时长
23 days
期刊介绍: European Urology Focus is a new sister journal to European Urology and an official publication of the European Association of Urology (EAU). EU Focus will publish original articles, opinion piece editorials and topical reviews on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, paediatric urology and sexual medicine. The editorial team welcome basic and translational research articles in the field of urological diseases. Authors may be solicited by the Editor directly. All submitted manuscripts will be peer-reviewed by a panel of experts before being considered for publication.
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