{"title":"大竹红景天代谢谱特征及抗缺氧成分评价。","authors":"Chun-Yan Ou, Xia Gao, Jia-Jia Wang, Xia-Lin Chen, Liang Cao, Zhen-Zhong Wang, Chen-Feng Zhang, Wei Xiao","doi":"10.1080/10286020.2024.2434550","DOIUrl":null,"url":null,"abstract":"<p><p>Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <i>p</i>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents.\",\"authors\":\"Chun-Yan Ou, Xia Gao, Jia-Jia Wang, Xia-Lin Chen, Liang Cao, Zhen-Zhong Wang, Chen-Feng Zhang, Wei Xiao\",\"doi\":\"10.1080/10286020.2024.2434550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <i>p</i>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-19\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-12-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2024.2434550\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2434550","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents.
Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, p-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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