p - Anisil作为活化烯烃E - to - Z光异构化的多功能催化剂-在药物和多肽后期修饰中的应用

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2025-02-17 DOI:10.1002/ejoc.202401338

Thanh V. Q. Nguyen , Peter R. Hansen

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引用次数: 0

摘要

采用高通量实验发现，对苯胺是肉桂酸衍生物和其他活化烯烃E - to - Z光异构化的高效和通用催化剂。这种新的催化体系可耐受药物化学中发现的许多官能团。这一发现使得直接从药物或多肽两步制备以前未知的Z -烯烃络合物成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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p‐Anisil as a Versatile Catalyst for the E‐to‐Z Photoisomerization of Activated Alkenes ‐ Application in Late‐Stage Modification of Small Molecule Drugs, Di‐ and Tripeptides

High‐throughput experimentation was employed to discover p‐Anisil as a highly effective and versatile catalysts for the E‐to‐Z photoisomerization of cinnamic acid derivatives and other activated alkenes. This new catalytic system tolerated a number of functional groups found in medicinal chemistry. The discovery enabled the preparation of previously unknown complex Z‐alkenes in two steps directly from drugs or peptides.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.