Dual-Time Point 68 Ga-FAPI-04 PET/CT Improves Tumor Delineation and Cervical Lymph Node Metastasis Identification in Patients With Head and Neck Squamous Cell Carcinoma.

Purpose: The purpose of this study was to evaluate the benefit of dual-time point 68 Ga-FAPI-04 PET/CT in staging head and neck squamous cell carcinoma (HNSCC).

Patients and methods: Sixty-nine treatment-naive patients with HNSCC were enrolled. Each patient underwent whole-body 68 Ga-FAPI-04 PET/CT at approximately 30 minutes postinjection and a delayed scan in head and neck region at 2 hours. Radiotracer uptake (SUV max ), tumor-to-background ratio, change in SUV max (∆SUV max ), retention index, diagnostic performance, and staging were explored. Histopathology was the reference standard.

Results: Primary tumors showed similar average SUV max between early (17.89) and delayed scans (17.86, P = 0.241). However, the tumor-to-background ratios of delayed imaging were all significantly higher than those of early imaging (all P < 0.001). In 38 patients who underwent neck dissection, metastatic lymph nodes showed higher mean SUV max on delayed imaging than on early imaging (early 10.53 ± 5.98 vs delayed 11.71 ± 6.36, P < 0.001), whereas nonmetastatic lymph nodes showed the opposite result (early 3.51 ± 0.51 vs delayed 2.58 ± 0.63, P = 0.002). The mean ∆SUV max and retention index of metastatic and nonmetastatic lymph nodes were 1.19 versus -0.93 and 12.79% versus -26.55%, respectively. N staging was correctly altered in 3 (3/38) patients based on delayed images.

Conclusions: Delayed 68 Ga-FAPI-04 PET/CT can effectively acquire high-contrast images, better tumor delineation, and detect hidden lesions near or within the tissues influenced by physiological uptake for HNSCC. In addition, dual-time point imaging adds diagnostic value for the differentiation of metastatic from nonmetastatic lymph nodes.