分位数结果自适应套索:分位数治疗效果逆概率加权估计的协变量选择。

IF 1.6 3区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Statistical Methods in Medical Research Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI:10.1177/09622802241299410
Takehiro Shoji, Jun Tsuchida, Hiroshi Yadohisa
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引用次数: 0

摘要

在使用倾向评分法估计治疗效果时,选择纳入倾向评分模型的协变量是很重要的。在倾向评分模型中纳入与结果无关的协变量导致治疗效果估计的偏倚和大方差。已经提出了许多数据驱动的协变量选择方法来选择与结果相关的协变量。然而,它们大多假设一个平均的治疗效果估计,可能不是设计来估计分位数治疗效果(qte),即治疗对结果分布分位数的影响。在QTE估计中,我们考虑将结果作为期望值和分位数点的两种关系类型。为了实现这一点,我们提出了一种数据驱动的倾向评分模型协变量选择方法,该方法允许选择与QTE估计结果的期望值和分位数相关的协变量。假设分位数回归模型为结果回归模型,以分位数回归模型的偏回归系数为权重,采用正则化方法进行协变量选择。将该方法应用于人工数据和华盛顿州金县出生的母亲和儿童数据集,比较现有方法和QTE估计器的性能。因此,所提出的方法在存在与结果的期望值和分位数相关的协变量时表现良好。
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Quantile outcome adaptive lasso: Covariate selection for inverse probability weighting estimator of quantile treatment effects.

When using the propensity score method to estimate the treatment effects, it is important to select the covariates to be included in the propensity score model. The inclusion of covariates unrelated to the outcome in the propensity score model led to bias and large variance in the estimator of treatment effects. Many data-driven covariate selection methods have been proposed for selecting covariates related to outcomes. However, most of them assume an average treatment effect estimation and may not be designed to estimate quantile treatment effects (QTEs), which are the effects of treatment on the quantiles of outcome distribution. In QTE estimation, we consider two relation types with the outcome as the expected value and quantile point. To achieve this, we propose a data-driven covariate selection method for propensity score models that allows for the selection of covariates related to the expected value and quantile of the outcome for QTE estimation. Assuming the quantile regression model as an outcome regression model, covariate selection was performed using a regularization method with the partial regression coefficients of the quantile regression model as weights. The proposed method was applied to artificial data and a dataset of mothers and children born in King County, Washington, to compare the performance of existing methods and QTE estimators. As a result, the proposed method performs well in the presence of covariates related to both the expected value and quantile of the outcome.

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来源期刊
Statistical Methods in Medical Research
Statistical Methods in Medical Research 医学-数学与计算生物学
CiteScore
4.10
自引率
4.30%
发文量
127
审稿时长
>12 weeks
期刊介绍: Statistical Methods in Medical Research is a peer reviewed scholarly journal and is the leading vehicle for articles in all the main areas of medical statistics and an essential reference for all medical statisticians. This unique journal is devoted solely to statistics and medicine and aims to keep professionals abreast of the many powerful statistical techniques now available to the medical profession. This journal is a member of the Committee on Publication Ethics (COPE)
期刊最新文献
Extension of Fisher's least significant difference method to multi-armed group-sequential response-adaptive designs. Generalized framework for identifying meaningful heterogenous treatment effects in observational studies: A parametric data-adaptive G-computation approach. The relative efficiency of staircase and stepped wedge cluster randomised trial designs. Bayesian mixture models for phylogenetic source attribution from consensus sequences and time since infection estimates. Jointly assessing multiple endpoints in pilot and feasibility studies.
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