Jin Wang , Yaohui Liu , Jinhai Xu , Peiyuan Li , Xiaoxi Xu , Shuo Zhang , Jie Yang , Xianxiu Xu
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Photoredox trifluoromethylation of isocyanides to access 2-trifluoromethylated quinolines and indoles†
We herein report a divergent synthesis of 2-CF3 substituted quinolines and indoles via photoredox radical trifluoromethylation of ortho-vinylphenylisocyanides. This mild and green protocol offers a broad substrate scope and good functional group tolerance. Mechanistic investigations revealed that the trifluoromethyl radical is generated through an EDA complex between Togni's reagent and a base under light irradiation.
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