Siqi Li, Baojun Sang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang
{"title":"改良居里和 SIOPEN 骨架评分系统在神经母细胞瘤 18F-AlF-NOTA-octreotide PET/CT 中的应用。","authors":"Siqi Li, Baojun Sang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang","doi":"10.1007/s12149-024-02006-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to explore the role of fluorine-18-aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-octreotide (<sup>18</sup>F-OC) positron emission tomography/computed tomography (PET/CT) in neuroblastoma (NB) and compared it with Iodine-123 labeled metaiodobenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy with single photon emission computed tomography/computed tomography (SPECT/CT), as well as to investigate the feasibility of the modified Curie scoring system and International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) skeleton scoring system applied in <sup>18</sup>F-OC PET/CT.</p><p><strong>Methods: </strong>Patients with pathologically confirmed NB underwent <sup>123</sup>I-MIBG scintigraphy with SPECT/CT and <sup>18</sup>F-OC PET/CT according the standard imaging protocols. The interval between the two imaging techniques ranged from 0 to 22 days (median interval: 9 days). The number of lesions in modified Curie scoring system and SIOPEN skeleton scoring system applied on <sup>123</sup>I-MIBG SPECT/CT and <sup>18</sup>F-OC PET/CT was compared.</p><p><strong>Results: </strong>A total of 50 NB patients (male: female = 25:25) with a median age of 62-month-old were enrolled. <sup>123</sup>I-MIBG and <sup>18</sup>F-OC imaging were positive in 22 patients and negative in 27 patients. 1 patient had positive <sup>18</sup>F-OC but negative <sup>123</sup>I-MIBG results (p = 1.000). In lesion-based analysis, <sup>18</sup>F-OC PET/CT revealed more positive lesions than <sup>123</sup>I-MIBG scintigraphy with SPECT/CT (57 vs. 44, p < 0.001), regardless of bone/bone marrow lesions (43 vs. 37, p = 0.031) or soft tissue lesions (14 vs. 7, p = 0.016). The Curie scores of the two imaging techniques showed a significant difference (p = 0.047), whereas no statistic difference for SIOPEN scores (p = 0.688). The Curie and SIOPEN scores were significantly higher in patients with the presence of MYCN amplification or positive bone marrow puncture result (p < 0.05).</p><p><strong>Conclusion: </strong><sup>18</sup>F-OC could be used in the evaluation of NB, and the modified Curie scoring system could be used to semi-quantify the disease extent of NB in <sup>18</sup>F-OC PET/CT.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of modified Curie and SIOPEN skeleton scoring systems in <sup>18</sup>F-AlF-NOTA-octreotide PET/CT for neuroblastoma.\",\"authors\":\"Siqi Li, Baojun Sang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang\",\"doi\":\"10.1007/s12149-024-02006-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The study aimed to explore the role of fluorine-18-aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-octreotide (<sup>18</sup>F-OC) positron emission tomography/computed tomography (PET/CT) in neuroblastoma (NB) and compared it with Iodine-123 labeled metaiodobenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy with single photon emission computed tomography/computed tomography (SPECT/CT), as well as to investigate the feasibility of the modified Curie scoring system and International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) skeleton scoring system applied in <sup>18</sup>F-OC PET/CT.</p><p><strong>Methods: </strong>Patients with pathologically confirmed NB underwent <sup>123</sup>I-MIBG scintigraphy with SPECT/CT and <sup>18</sup>F-OC PET/CT according the standard imaging protocols. The interval between the two imaging techniques ranged from 0 to 22 days (median interval: 9 days). The number of lesions in modified Curie scoring system and SIOPEN skeleton scoring system applied on <sup>123</sup>I-MIBG SPECT/CT and <sup>18</sup>F-OC PET/CT was compared.</p><p><strong>Results: </strong>A total of 50 NB patients (male: female = 25:25) with a median age of 62-month-old were enrolled. <sup>123</sup>I-MIBG and <sup>18</sup>F-OC imaging were positive in 22 patients and negative in 27 patients. 1 patient had positive <sup>18</sup>F-OC but negative <sup>123</sup>I-MIBG results (p = 1.000). In lesion-based analysis, <sup>18</sup>F-OC PET/CT revealed more positive lesions than <sup>123</sup>I-MIBG scintigraphy with SPECT/CT (57 vs. 44, p < 0.001), regardless of bone/bone marrow lesions (43 vs. 37, p = 0.031) or soft tissue lesions (14 vs. 7, p = 0.016). The Curie scores of the two imaging techniques showed a significant difference (p = 0.047), whereas no statistic difference for SIOPEN scores (p = 0.688). The Curie and SIOPEN scores were significantly higher in patients with the presence of MYCN amplification or positive bone marrow puncture result (p < 0.05).</p><p><strong>Conclusion: </strong><sup>18</sup>F-OC could be used in the evaluation of NB, and the modified Curie scoring system could be used to semi-quantify the disease extent of NB in <sup>18</sup>F-OC PET/CT.</p>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12149-024-02006-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12149-024-02006-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Application of modified Curie and SIOPEN skeleton scoring systems in 18F-AlF-NOTA-octreotide PET/CT for neuroblastoma.
Objective: The study aimed to explore the role of fluorine-18-aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-octreotide (18F-OC) positron emission tomography/computed tomography (PET/CT) in neuroblastoma (NB) and compared it with Iodine-123 labeled metaiodobenzylguanidine (123I-MIBG) scintigraphy with single photon emission computed tomography/computed tomography (SPECT/CT), as well as to investigate the feasibility of the modified Curie scoring system and International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) skeleton scoring system applied in 18F-OC PET/CT.
Methods: Patients with pathologically confirmed NB underwent 123I-MIBG scintigraphy with SPECT/CT and 18F-OC PET/CT according the standard imaging protocols. The interval between the two imaging techniques ranged from 0 to 22 days (median interval: 9 days). The number of lesions in modified Curie scoring system and SIOPEN skeleton scoring system applied on 123I-MIBG SPECT/CT and 18F-OC PET/CT was compared.
Results: A total of 50 NB patients (male: female = 25:25) with a median age of 62-month-old were enrolled. 123I-MIBG and 18F-OC imaging were positive in 22 patients and negative in 27 patients. 1 patient had positive 18F-OC but negative 123I-MIBG results (p = 1.000). In lesion-based analysis, 18F-OC PET/CT revealed more positive lesions than 123I-MIBG scintigraphy with SPECT/CT (57 vs. 44, p < 0.001), regardless of bone/bone marrow lesions (43 vs. 37, p = 0.031) or soft tissue lesions (14 vs. 7, p = 0.016). The Curie scores of the two imaging techniques showed a significant difference (p = 0.047), whereas no statistic difference for SIOPEN scores (p = 0.688). The Curie and SIOPEN scores were significantly higher in patients with the presence of MYCN amplification or positive bone marrow puncture result (p < 0.05).
Conclusion: 18F-OC could be used in the evaluation of NB, and the modified Curie scoring system could be used to semi-quantify the disease extent of NB in 18F-OC PET/CT.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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