IF 1.9 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH American Journal of Tropical Medicine and Hygiene Pub Date : 2024-12-10 DOI:10.4269/ajtmh.24-0416
Anju Dinkar, Jitendra Singh, Pradyot Prakash, Ranjeet Kumar Vishwakarma
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摘要

登革热是热带和亚热带地区新出现和再次出现的一种严重威胁全球公共卫生的虫媒病毒。印度城市和农村地区登革热疫情不断上升,与所有四种血清型都有关联。本研究旨在考察 2020 年至 2021 年印度北方邦东部一家三级医疗中心流行的登革热病毒(DENV)的血清型和基因型。这项回顾性横断面观察研究涉及 2021 年 1 月至 2022 年 12 月的登革热患者。通过巢式反转录酶聚合酶链反应(RT-PCR)扩增部分CprM(511-bp)基因,然后进行测序,对循环中的登革热病毒进行基因分析。只有 NS1 抗原阳性者(n = 581)才被纳入研究。共有 204 例(35.1%)血清反应呈阳性,其中 2021 年 257 例中有 96 例(37.4%),2022 年 324 例中有 108 例(33.3%)。男性患者最多,有 119 例(58.3%)。登革热的巢式RT-PCR检测显示,除DENV-4外,有三种DENV-1至DENV-3。DENV-2和DENV-3是最主要的血清型,分别有98例(48%)和94例(46%)。相反,DENV-1 的发病率最低,只有 3 例(1.6%)。不幸的是,204 个病例中有 35 个(17.2%)死亡。DENV-2 的死亡率最高,有 23 人死亡(65.7%)。在 DENV-3 病例中,有 9 人(25.7%)死亡。这项研究揭示了印度各地区 DENV 血清型流行率的差异。如果能在登革热季节早期发现最常见血清型和基因型的地区差异,分子监测就可以预测登革热的主要爆发和严重程度。
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Prevalence of Different Dengue Serotypes in Northern India, 2021-2022: A Tertiary Care Hospital-Based Study.

Dengue fever is a substantial emerging and reemerging arboviral virus in tropical and subtropical areas that seriously threatens public health worldwide. India is experiencing rising dengue epidemics in urban and rural regions linked to all four serotypes. The objective is to examine the serotypes and genotypes of the circulating dengue virus (DENV) at a tertiary care center in eastern Uttar Pradesh, India, from 2020 to 2021. This retrospective cross-sectional observational study involved dengue patients from January 2021 to December 2022. The genetic analysis of the circulating DENV was conducted by amplifying the partial CprM (511-bp) gene using nested reverse transcriptase polymerase chain reaction (RT-PCR), followed by sequencing. Only those positive for NS1 antigen (n = 581) were included in the study. A total of 204 cases (35.1%) were seropositive, with 96 cases (37.4%) out of 257 in 2021 and 108 cases (33.3%) out of 324 in 2022. With 119 cases (58.3%), men were most affected. The nested RT-PCR for dengue revealed three DENV-1 to DENV-3, except for DENV-4. DENV-2 and DENV-3 were the most predominant serotypes, with 98 (48%) and 94 (46%) cases, respectively. Conversely, DENV-1 was the least prevalent with cases 3 (1.6%). Unfortunately, 35 (17.2%) of the 204 cases died. DENV-2 had the highest mortality rate, with 23 deaths (65.7%). In cases with DENV-3, nine (25.7%) died. This study revealed regional disparities in DENV serotype prevalence in India. If regional differences in the most common serotypes and genotypes are identified early in the season, molecular surveillance may predict major dengue outbreaks and severity.

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来源期刊
American Journal of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.20
自引率
3.00%
发文量
508
审稿时长
3 months
期刊介绍: The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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