COVID-19 后亚急性或慢性咳嗽门诊患者的特征和临床疗效:一项真实世界研究。

IF 2.3 3区 生物学 Q2 MULTIDISCIPLINARY SCIENCES PeerJ Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.7717/peerj.18705
Chun Yao, Dongliang Cheng, Wenhong Yang, Yun Guo, Tong Zhou
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引用次数: 0

摘要

背景:有关 COVID 后咳嗽的特征和治疗方法的研究十分有限。这项真实世界的研究调查了亚急性或慢性后 COVID 咳嗽的门诊患者,旨在明确该人群的特征和治疗方案:方法:我们在 2023 年 8 月至 2024 年 2 月期间从门诊部招募了符合条件的患者。在初诊和随后的随访中收集了全面的临床数据、处方和患者报告的咳嗽严重程度:结果:共纳入 141 名患者,年龄为结果:共纳入 141 名患者,年龄为(42 ± 14)岁,其中 70% 为女性。咳嗽持续时间中位数为 8 周(四分位数间距为 4-12 周)。60%的患者表现为干咳,其余为有痰咳嗽。半数以上的患者(54%)表示喉部感觉异常。21%的患者白天咳嗽,32%的患者持续咳嗽,48%的患者夜间咳嗽。复方甲氧那明胶囊是处方最多的药物,但我们的研究发现,ICS/LABA是最有效的药物,其次是复方甲氧那明胶囊、孟鲁司特和中成药:结论:女性 COVID 后咳嗽的发病率更高,我们的研究建议首选 ICS/LABA 治疗。这些发现需要通过更大规模的前瞻性研究来验证。
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Characterization and clinical outcomes of outpatients with subacute or chronic post COVID-19 cough: a real-world study.

Background: Limited research exists on the features and management of post-COVID cough. This real-world study investigates outpatients with subacute or chronic post-COVID cough, aiming to delineate characteristics and regimen responses within the population.

Method: We enrolled eligible patients from our outpatient unit between August 2023 and February 2024. Comprehensive clinical data, prescriptions, and patient-reported cough severity were collected during the primary visit and subsequent follow-ups.

Result: A total of 141 patients, aged: 42 ± 14 years old, were included, with 70% being female. The median cough duration was 8 weeks (interquartile range 4-12 weeks). Sixty percent presented with a dry cough, while the rest had coughs with phlegm. Over half reported abnormal laryngeal sensations (54%). Twenty-one percent coughed during the day, while 32% coughed constantly, and 48% experienced nocturnal episodes. Compound methoxyphenamine capsules were the most prescribed, but our study found ICS/LABA to be the most effective, followed by compound methoxyphenamine capsules, montelukast, and Chinese patent drugs.

Conclusion: Females exhibit a higher prevalence of post-COVID cough, and our study recommends ICS/LABA as the preferred treatment. These findings warrant validation through larger, prospectively designed studies.

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来源期刊
PeerJ
PeerJ MULTIDISCIPLINARY SCIENCES-
CiteScore
4.70
自引率
3.70%
发文量
1665
审稿时长
10 weeks
期刊介绍: PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.
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