{"title":"无症状健康非糖尿病绝经后妇女亚临床动脉粥样硬化的预测因素。","authors":"Jehona Ismaili, Pranvera Ibrahimi, Venera Berisha-Muharremi, Rona Karahoda, Mimoza Berbatovci-Ukimeraj, Nora Istrefi, Bujar Gjikolli, Arlind Batalli, Afrim Poniku, Shpend Elezi, Michael Y. Henein, Gani Bajraktari","doi":"10.1111/cpf.12920","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Aim</h3>\n \n <p>Cardiovascular disease progresses after menopause. Conventional risk factors, particularly diabetes, for atherosclerosis are well-established predictors of phenotypic arterial disease. The aim of this study is to assess the predictors of subclinical atherosclerosis in asymptomatic non-diabetic postmenopausal women.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This prospective study included 117 consecutive postmenopausal women (mean age 59 ± 7 years) referred from the outpatient Rheumatology Clinic of the University Clinical Centre of Kosovo, recruited between September 2021 and December 2022. Clinical, biochemical, carotid ultrasound and coronary CT angiography data were analysed. Subclinical atherosclerosis was diagnosed when plaque and/or carotid intima-media thickness >1.00 mm were present.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Women who had subclinical atherosclerosis had higher erythrocyte sedimentation (<i>p</i> = 0.022), higher total cholesterol (<i>p</i> = 0.013), higher CAC score (<i>p</i> = 0.017), and higher prevalence of CAC > 100 HU and CAC > 400 HU (<i>p</i> = 0.017 and <i>p</i> = 0.034, respectively) compared to those without subclinical atherosclerosis. Women who had mild coronary calcification (CAC score ≥10 HU) were older (<i>p</i> = 0.005), in longer menopause (<i>p</i> = 0.005), had thicker CIMT (<i>p</i> = 0.008) with higher prevalence (<i>p</i> = 0.03) compared to those with CAC score <10 HU. Women with moderate coronary calcification (CAC score ≥100 HU) had higher triglycerides, worse CIMT (<i>p</i> = 0.005) with higher prevalence (<i>p</i> = 0.039) compared to those with CAC score <100 HU. In multivariate analysis [odds ratio 95% confidence interval], age [1.101 (1.032–1.174), <i>p</i> = 0.037] and cholesterol [2.020 (1.225–3.331), <i>p</i> = 0.006] independently predicted the presence of subclinical atherosclerosis.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In addition to the impact of age, hypercholesterolaemia is an important predictor of subclinical atherosclerosis in non-diabetic postmenopausal women.</p>\n </section>\n </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12920","citationCount":"0","resultStr":"{\"title\":\"Predictors of subclinical atherosclerosis in asymptomatic healthy non-diabetic postmenopausal women\",\"authors\":\"Jehona Ismaili, Pranvera Ibrahimi, Venera Berisha-Muharremi, Rona Karahoda, Mimoza Berbatovci-Ukimeraj, Nora Istrefi, Bujar Gjikolli, Arlind Batalli, Afrim Poniku, Shpend Elezi, Michael Y. Henein, Gani Bajraktari\",\"doi\":\"10.1111/cpf.12920\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background and Aim</h3>\\n \\n <p>Cardiovascular disease progresses after menopause. Conventional risk factors, particularly diabetes, for atherosclerosis are well-established predictors of phenotypic arterial disease. The aim of this study is to assess the predictors of subclinical atherosclerosis in asymptomatic non-diabetic postmenopausal women.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This prospective study included 117 consecutive postmenopausal women (mean age 59 ± 7 years) referred from the outpatient Rheumatology Clinic of the University Clinical Centre of Kosovo, recruited between September 2021 and December 2022. Clinical, biochemical, carotid ultrasound and coronary CT angiography data were analysed. Subclinical atherosclerosis was diagnosed when plaque and/or carotid intima-media thickness >1.00 mm were present.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Women who had subclinical atherosclerosis had higher erythrocyte sedimentation (<i>p</i> = 0.022), higher total cholesterol (<i>p</i> = 0.013), higher CAC score (<i>p</i> = 0.017), and higher prevalence of CAC > 100 HU and CAC > 400 HU (<i>p</i> = 0.017 and <i>p</i> = 0.034, respectively) compared to those without subclinical atherosclerosis. Women who had mild coronary calcification (CAC score ≥10 HU) were older (<i>p</i> = 0.005), in longer menopause (<i>p</i> = 0.005), had thicker CIMT (<i>p</i> = 0.008) with higher prevalence (<i>p</i> = 0.03) compared to those with CAC score <10 HU. Women with moderate coronary calcification (CAC score ≥100 HU) had higher triglycerides, worse CIMT (<i>p</i> = 0.005) with higher prevalence (<i>p</i> = 0.039) compared to those with CAC score <100 HU. In multivariate analysis [odds ratio 95% confidence interval], age [1.101 (1.032–1.174), <i>p</i> = 0.037] and cholesterol [2.020 (1.225–3.331), <i>p</i> = 0.006] independently predicted the presence of subclinical atherosclerosis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>In addition to the impact of age, hypercholesterolaemia is an important predictor of subclinical atherosclerosis in non-diabetic postmenopausal women.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10504,\"journal\":{\"name\":\"Clinical Physiology and Functional Imaging\",\"volume\":\"45 1\",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12920\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Physiology and Functional Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12920\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Physiology and Functional Imaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12920","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Predictors of subclinical atherosclerosis in asymptomatic healthy non-diabetic postmenopausal women
Background and Aim
Cardiovascular disease progresses after menopause. Conventional risk factors, particularly diabetes, for atherosclerosis are well-established predictors of phenotypic arterial disease. The aim of this study is to assess the predictors of subclinical atherosclerosis in asymptomatic non-diabetic postmenopausal women.
Methods
This prospective study included 117 consecutive postmenopausal women (mean age 59 ± 7 years) referred from the outpatient Rheumatology Clinic of the University Clinical Centre of Kosovo, recruited between September 2021 and December 2022. Clinical, biochemical, carotid ultrasound and coronary CT angiography data were analysed. Subclinical atherosclerosis was diagnosed when plaque and/or carotid intima-media thickness >1.00 mm were present.
Results
Women who had subclinical atherosclerosis had higher erythrocyte sedimentation (p = 0.022), higher total cholesterol (p = 0.013), higher CAC score (p = 0.017), and higher prevalence of CAC > 100 HU and CAC > 400 HU (p = 0.017 and p = 0.034, respectively) compared to those without subclinical atherosclerosis. Women who had mild coronary calcification (CAC score ≥10 HU) were older (p = 0.005), in longer menopause (p = 0.005), had thicker CIMT (p = 0.008) with higher prevalence (p = 0.03) compared to those with CAC score <10 HU. Women with moderate coronary calcification (CAC score ≥100 HU) had higher triglycerides, worse CIMT (p = 0.005) with higher prevalence (p = 0.039) compared to those with CAC score <100 HU. In multivariate analysis [odds ratio 95% confidence interval], age [1.101 (1.032–1.174), p = 0.037] and cholesterol [2.020 (1.225–3.331), p = 0.006] independently predicted the presence of subclinical atherosclerosis.
Conclusions
In addition to the impact of age, hypercholesterolaemia is an important predictor of subclinical atherosclerosis in non-diabetic postmenopausal women.
期刊介绍：
Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest.
Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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