Jessica A Davis, Em Seiler, Rod Ghassemzadeh, Tracy Baust, Brian Firek, Lauren Lorenzi Quigley, Jacqueline Kreutzer, Dianxu Ren, Michael J Morowitz, Judith M Martin
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Prevalence and Patterns of Antibiotic Administration in Neonates With Critical Congenital Heart Defects.
Background: Although data exists demonstrating widespread antibiotic use across other critically ill neonatal populations, there are limited data regarding the frequency of empiric antibiotic use among neonates with critical congenital heart defects (CCHD). The purpose of this study is to describe prevalence of antibiotic treatment in the first 28 days of life in a cohort of neonates with CCHDs.
Methods: A secondary analysis of retrospective electronic health record data of neonates admitted to a Pennsylvania pediatric hospital for cardiac surgery (2016-2020). Descriptive statistics were generated to show antibiotic treatment days and indications for use. Pearson Chi-Square and multivariable regression models were used to analyze predictors.
Results: Seventy-four neonates were included. Fifty neonates (68%) received antibiotics for reasons other than postoperative prophylaxis. Two (3%) had confirmed bacteremia.
Conclusions: Antibiotic administration was prevalent in this cohort. Future work should elucidate population prevalence of empirical antibiotic use, identify potential consequences, and design interventions to prevent overuse.
期刊介绍：
The Journal of Perinatal and Neonatal Nursing (JPNN) strives to advance the practice of evidence-based perinatal and neonatal nursing through peer-reviewed articles in a topic-oriented format. Each issue features scholarly manuscripts, continuing education options, and columns on expert opinions, legal and risk management, and education resources. The perinatal focus of JPNN centers around labor and delivery and intrapartum services specifically and overall perinatal services broadly. The neonatal focus emphasizes neonatal intensive care and includes the spectrum of neonatal and infant care outcomes. Featured articles for JPNN include evidence-based reviews, innovative clinical programs and projects, clinical updates and education and research-related articles appropriate for registered and advanced practice nurses.
The primary objective of The Journal of Perinatal & Neonatal Nursing is to provide practicing nurses with useful information on perinatal and neonatal nursing. Each issue is PEER REVIEWED and will feature one topic, to be covered in depth. JPNN is a refereed journal. All manuscripts submitted for publication are peer reviewed by a minimum of three members of the editorial board. Manuscripts are evaluated on the basis of accuracy and relevance of content, fit with the journal purpose and upcoming issue topics, and writing style. Both clinical and research manuscripts applicable to perinatal and neonatal care are welcomed.
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