探索含杂环配体的面部三羰基铼和三羰基铼化合物的抗癌活性。

Candace Davison, Shabaaz Abdullah, Christie Jane Smit, Phakamani Dlamini, Irvin Noel Booysen, Jo-Anne de la Mare
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Probing the anticancer activities of facial trioxorhenium and tricarbonylrhenium compounds with heterocyclic ligands.

The cytotoxicity of four rhenium compounds: fac-[ReO3(impy)CH3] (1) (impy = 2-(1H-imidazol-2-yl)pyridine), fac-[Re(CO)3(bzimpy)Cl] (2) (bzimpy = 2-(2-pyridyl)benzimidazole), fac-[Re(CO)3(bibzimpy)Cl] (3) (bibzimpy = 2,6-bis(2-benzimidazolyl)pyridine) and fac-[Re(CO)3(impy)Cl] (4) was assessed against cancer cell lines, namely, the cervical hormone-responsive HeLa and the triple-negative breast cancer (TNBC) HCC70 lines versus a non-tumorigenic control breast epithelial cell line, MCF12A. A rare facial trioxorhenium(VII) compound 1 was characterized via various physicochemical techniques. The rhenium compounds 1 - 4 were, in general, more cytotoxic to HeLa cells, compared to the TNBC HCC70 line, displaying half maximal inhibitory concentration (IC50) values in the micromolar range, however, the compounds were not convincingly selective for cancer cells over non-cancerous cells. In particular, compound 4 was highly cytotoxic towards HCC70, HeLa, and MCF12A cells, displaying low micromolar toxicity with IC50 values of 6.57 ± 1.11 μM, 8.88 ± 1.07 and 9.41 ± 1.04 μM in these three cell lines, respectively and was selected for further study as it displayed the greatest cytotoxicity against the highly treatment-resistant HCC70 TNBC cell line. Compound 4 was able to both bind to genomic DNA and act as an intercalator of CT-DNA, however, this did not lead to DNA damage as assessed by a comet assay. In addition, Compound 4 displayed a long-term dose-dependent effect on colony formation and long-term survival as a proxy of in vivo toxicity.

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Myriscagayanone C, a new compound from the fruit of myristica cagayanensis, inhibits fMLP-induced respiratory bursts by specifically preventing Akt translocation in human neutrophils. Review on the role of autophagy in the toxicity of nanoparticles and the signaling pathways involved. YTHDF2 promotes arsenic-induced malignant phenotypes by degrading PIDD1 mRNA in human keratinocytes. Nrf2 inhibition and NCOA4-mediated ferritinophagy activation synergistically exacerbated S-3'-hydroxy-7', 2', 4'-trimethoxyisoxane induced ferroptosis in lung cancer cells. Probing the anticancer activities of facial trioxorhenium and tricarbonylrhenium compounds with heterocyclic ligands.
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