生物光子学技术评价2型糖尿病患者血液微循环和微流变参数。

D A Umerenkov, P B Ermolinskiy, A E Lugovtsov, A A Fabrichnova, Yu I Gurfinkel, L I Dyachuk, A V Priezzhev
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摘要

在这项研究中,使用激光聚集测定法和光学镊子法在体外测量了血液微循环和微流变参数,并使用数字毛细血管镜法在体内进行了测量。结果表明,在 2 型糖尿病患者中,通过狭窄毛细血管的红细胞聚集体数量增加会导致毛细血管血流速度明显下降,这可以用全血粘度增加和红细胞变形能力下降来解释。此外,与对照组相比,该组患者的红细胞聚集率、聚集体的流体力学强度、红细胞聚集力和分解力在统计学上都有显著增加。我们证明了使用这些方法评估血液微流变学和微循环参数变化的可能性。
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Assessment of Microcirculation and Microrheological Parameters of Blood in Patients With Type 2 Diabetes Mellitus Using Biophotonics Techniques.

In this study, the parameters of blood microcirculation and microrheology were measured using the methods of laser aggregometry and optical tweezers in vitro, as well as the method of digital capillaroscopy in vivo. It was shown that in patients suffering from type 2 diabetes mellitus, an increase in the number of RBC aggregates passing through the narrow capillaries leads to a significant decrease in the velocity of the capillary blood flow, which can be explained by the increased viscosity of the whole blood and decreased deformability of RBCs. Also, for the group of patients, a statistically significant increase in the rate of RBC aggregation and the hydrodynamic strength of aggregates, RBC aggregation and disaggregation forces were observed compared to the control group. We have demonstrated the possibility of using these methods to assess changes in microrheological and microcirculatory parameters of the blood.

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