在化疗基础上加用blinatumomab可降低标准风险儿科B-ALL的复发风险

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-12-17 DOI:10.1038/s41571-024-00980-1
Peter Sidaway
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引用次数: 0

摘要

尽管取得了相当大的进展,但b细胞急性淋巴细胞白血病(B-ALL)仍然是儿童癌症相关死亡的主要原因。现在,来自III期AALL1731试验的数据表明,在化疗中加入CD19 × CD3双特异性T细胞参与者blinatumomab可显著改善具有平均或高风险疾病复发的标准风险B-ALL患者的预后。在这项试验中,1440名患有标准风险B-ALL的儿童(1-10岁),基于诱导治疗完成后的细胞遗传学特征和最小残留疾病(MRD)状态,复发风险平均(n = 835)或高(n = 605),随机分配(1:1)接受诱导后(平均风险患者)或固化后(高风险患者)化疗两个周期,与不使用blinatumomab相比。无病生存期(DFS)是主要终点。
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Adding blinatumomab to chemotherapy reduces recurrence risk in standard-risk paediatric B-ALL
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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