总状杜鹃花中萜类化合物及其抗炎活性。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI:10.1080/10286020.2024.2431813

Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei

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引用次数: 0

摘要

从总状杜鹃（Rhododendron racemosum）中分离得到3个半萜类化合物，包括1个新化合物ranhuadujuanine E(1)、1个新天然产物甲基(E)-3-（3,7-二甲基-2,6-二烯-1-基）-2,4-二羟基-6-甲基苯甲酸酯(2)、1个已知化合物ranhuadujuanine D(3)和2个已知的倍半萜类化合物（4-5）。通过广泛的光谱分析对其结构进行了鉴定，并利用Snatzke方法确定了化合物1中C-6′的绝对构型。化合物1 ~ 3对lps诱导的RAW264.7细胞NO释放有抑制作用。

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Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities.

Three meroterpenoids, including one new compound, ranhuadujuanine E (1), one new natural product, methyl (E)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (2), and one known compound, ranhuadujuanine D (3), along with two known sesquiterpenoids (4-5) were isolated from Rhododendron racemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound 1 was assigned by using Snatzke's method. Compounds 1-3 had inhibitory effects on LPS-induced NO release in RAW264.7 cells.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.