细胞流感疫苗与蛋流感疫苗预防2018 -2023流感季节18-64岁成人流感住院的比较效果

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2024-12-18 DOI:10.1111/irv.70025

Emily Rayens, Jennifer H. Ku, Lina S. Sy, Lei Qian, Bradley K. Ackerson, Yi Luo, Julia E. Tubert, Gina S. Lee, Punam P. Modha, Yoonyoung Park, Tianyu Sun, Evan J. Anderson, Hung Fu Tseng

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摘要

本回顾性队列研究评估了标准剂量细胞流感疫苗与蛋流感疫苗在预防2022-2023流感季节18-64岁成人流感住院方面的比较疫苗有效性（cVE）。该队列包括接受≥1剂流感疫苗的符合条件的Kaiser Permanente南加州会员（n = 848,334）。在18- 49岁的队列中，流感住院的校正cVE为-10.1% （95% CI: -49.8%, 37.8%）。在50- 64岁的队列中，调整后的cVE为14.9%（-33.8%,52.1%）。在2022-2023年流感季节，基于细胞和基于鸡蛋的流感疫苗对18-64岁成年人流感住院的保护作用相当。

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Comparative Effectiveness of Cell-Based Versus Egg-Based Influenza Vaccines in Prevention of Influenza Hospitalization During the 2022–2023 Season Among Adults 18–64 Years

This retrospective cohort study evaluated the comparative vaccine effectiveness (cVE) of licensed standard-dose cell-based versus egg-based influenza vaccines in preventing influenza hospitalization among adults 18–64 years during the 2022–2023 season. The cohort included eligible Kaiser Permanente Southern California members who received ≥ 1 dose of influenza vaccine (n = 848,334). The adjusted cVE against influenza hospitalization was −10.1% (95% CI: −49.8%, 37.8%) in the 18- to 49-year-old cohort. In the 50- to 64-year-old cohort, the adjusted cVE was 14.9% (−33.8%, 52.1%). Cell-based and egg-based influenza vaccines conferred comparable protection against influenza hospitalization in adults 18–64 years of age in the 2022–2023 season.

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.