Kouharu Otsuki , Chihiro Hosoya , Riko Takamiya , Mayu Kimura , Takashi Kikuchi , Li Huang , Chin-Ho Chen , Wei Li
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The plants of the genus Daphne (Thymelaeaceae) are known to be sources of anti-HIV diterpenoids. Therefore, the present study focused on investigating the anti-HIV diterpenoids in Daphne pseudomezereum, for which the isolation of diterpenoids has not been previously reported. The results showed that three previously undescribed daphnane diterpenoids, onishibarins A–C (1–3), along with seven known compounds (4–10) were isolated from the fruits of Daphne pseudomezereum. Their structures were established by comprehensive analysis of physicochemical and spectroscopic data. Evaluation of the anti-HIV activity and cytotoxicity of the isolated compounds showed that compounds 1, 9, and 10 exhibited potent anti-HIV activity at EC50 = 1.26, 0.84, and 0.78 nM, respectively, with cytotoxicity at IC50 > 5 μM.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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